BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1.
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Summary
BAC-VACs per se, or in combination with genetic elements that support replicative amplification of the DNA in the cell nucleus, represent a useful new generation of DNA-based vaccination strategies for many viral and nonviral antigens.
- Type
- article
- Published
- 1999-10-26
- Cited by
- 76
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W10535985
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23166720
Keywords
Diode, Cathode, Step recovery diode, Cathode ray, Materials science
References
- Classics of Medicine and Surgery
- Gene Transfer into Hepatocytes Mediated by Helper Virus-Free HSV/AAV Hybrid Vectors
- Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias
- Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli
- Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes.
- Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants
- T cell receptor antagonist peptides induce positive selection.
- Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.
- Epitope specificity of H-2Kb-restricted, HSV-1-, and HSV-2-cross-reactive cytotoxic T lymphocyte clones.
- Green fluorescent protein as a reporter for retrovirus and helper virus‐free HSV‐1 amplicon vector‐mediated gene transfer into neural cells in culture and in vivo
- Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?
- Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.
- DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.
- Tipping the scales of herpes simplex virus reactivation: The important responses are local
- Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge.
- Role of neutralizing antibodies and T-cells in pathogenesis of herpes simplex virus infection in congenitally athymic mice.
- Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization
- Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1.
- An Immunologist's View of Herpes Simplex Keratitis: Thygeson Lecture 1996, Presented at the Ocular Microbiology and Immunology Group Meeting, October 26, 1996
- Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA.
Cited by
- Assessment of a cellular vaccination approach consisting of crawling dendritic cells (CDCs) transduced with HSV-1-†pac vectors
- Engineering of cytomegalovirus genomes for recombinant live herpesvirus vaccines.
- Visions on the future of veterinary virology
- Concept of Immunomics: A New Frontier in the Battle for Gene Function?
- IMMOBILIZED COBALT AFFINITY PURIFICATION FOR HSV-1 BASED GENE THERAPY VECTORS
- Klonierung und Mutagenese des Bovinen Herpesvirus Typ 1 als ein infektiöses künstliches bakterielles Chromosom (bacterial artificial chromosome, BAC)
- A kinetic study of gamma interferon production in herpes simplex virus-1 DNA prime-protein boost regimen comparing to DNA or subunit vaccination
- HSV Recombinant Vectors for Gene Therapy.
- Bacterial genomics: the use of DNA microarrays and bacterial artificial chromosomes.
- Vaccination of Mice with Bacteria Carrying a Cloned Herpesvirus Genome Reconstituted In Vivo
- Protective T-Cell-Based Immunity Induced in Neonatal Mice by a Single Replicative Cycle of Herpes Simplex Virus
- Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine.
- Viral vectored immunocontraception: screening of multiple fertility antigens using murine cytomegalovirus as a vaccine vector.
- Replication-defective viruses as vaccines and vaccine vectors.
- Use of a current varicella vaccine as a live polyvalent vaccine vector.
- Construction of an infectious Marek's disease virus bacterial artificial chromosome and characterization of protection induced in chickens.
- Forward with BACs: new tools for herpesvirus genomics.
- Herpesvirus BACs: Past, Present, and Future
- Multi-antigenic DNA immunization using herpes simplex virus type 2 genomic fragments
- Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
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