Construction of an infectious Marek's disease virus bacterial artificial chromosome and characterization of protection induced in chickens.
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Summary
In vitro, the BAC-derived virus had similar biological characteristics and growth kinetics as the wild-type parental and recombinant viruses, and chickens immunized with BAC derivatives by various delivery mechanisms acquired protection against virulent MDV challenge.
- Type
- article
- Published
- 2009-03-01
- Cited by
- 22
- References
- 29
- OpenAlex
- https://openalex.org/W2009667364
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206663667
Keywords
Biology, Virology, Bacterial artificial chromosome, Virus, Recombinant DNA
References
- Rapid modification of bacterial artificial chromosomes by ET-recombination.
- BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1.
- Protective efficacy of Marek's disease vaccines.
- A new logic for DNA engineering using recombination in Escherichia coli
- Oncogenicity of Virulent Marek's Disease Virus Cloned as Bacterial Artificial Chromosomes
- Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis
- Transfection of chicken embryo fibroblasts with Marek's disease virus DNA.
- DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.
- Forward with BACs: new tools for herpesvirus genomics.
- Polyvalent Marek's disease vaccines: safety, efficacy and protective synergism in chickens with maternal antibodies.
- Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome.
- Increased virulence of Marek's disease virus field isolates.
- Marek's disease virus: from miasma to model
- Genetic Evidence of an Essential Role for Cytomegalovirus Small Capsid Protein in Viral Growth
- Efficient and precise engineering of a 200 kb β-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system
- Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek's disease.
- The Protein Encoded by the US3 Orthologue of Marek's Disease Virus Is Required for Efficient De-Envelopment of Perinuclear Virions and Involved in Actin Stress Fiber Breakdown
- The products of the UL10 (gM) and the UL49.5 genes of Marek's disease virus serotype 1 are essential for virus growth in cultured cells.
- Reconstitution of Marek's Disease Virus Serotype 1 (MDV-1) from DNA Cloned as a Bacterial Artificial Chromosome and Characterization of a Glycoprotein B-Negative MDV-1 Mutant
- Replication-Competent Bacterial Artificial Chromosomes of Marek's Disease Virus: Novel Tools for Generation of Molecularly Defined Herpesvirus Vaccines
Cited by
- Genome-wide analysis of Marek's disease virus proteins and their role in modulating the innate immune response in chickens
- Recombinant duck enteritis virus expressing the HA gene from goose H5 subtype avian influenza virus.
- Functional evaluation of the role of reticuloendotheliosis virus long terminal repeat (LTR) integrated into the genome of a field strain of Marek's disease virus.
- Marek’s disease viruses lacking either R-LORF10 or LORF4 have altered virulence in chickens
- Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease.
- Progress toward the development of polyvalent vaccination strategies against multiple viral infections in chickens using herpesvirus of turkeys as vector
- Construction of Recombinant Marek's Disease Virus (rMDV) Co-Expressing AIV-H9N2-NA and NDV-F Genes under Control of MDV's Own Bi-Directional Promoter
- Avirulent Marek’s Disease Virus Type 1 Strain 814 Vectored Vaccine Expressing Avian Influenza (AI) Virus H5 Haemagglutinin Induced Better Protection Than Turkey Herpesvirus Vectored AI Vaccine
- Expression of HA of HPAI H5N1 Virus at US2 Gene Insertion Site of Turkey Herpesvirus Induced Better Protection than That at US10 Gene Insertion Site
- Construction of recombinant Marek's disease virus (MDV) lacking the meq oncogene and co-expressing AIV-H9N2 HA and NA genes under control of exogenous promoters.
- A MEQ-Deleted Marek's Disease Virus Cloned as a Bacterial Artificial Chromosome Is a Highly Efficacious Vaccine
- GENERATION OF RECOMBINANT MAREK'S DISEASE VIRUSES IN VIVO
- DEVELOPMENT OF NOVEL VACCINE CANDIDATES FOR MEASLES
- AVIAN VIRAL VECTOR VACCINES FOR INFECTIOUS BURSAL DISEASE
- Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.
- Recombinant Marek’s disease virus type 1 provides full protection against very virulent Marek’s and infectious bursal disease viruses in chickens
- Evaluation and Identification of Marek's Disease Virus BAC Clones as Standardized Reagents for Research
- Characterization of a Gallid herpesvirus 2 strain with novel reticuloendotheliosis virus long terminal repeat inserts
- Comparison of different sites in recombinant Marek's disease virus for the expression of green fluorescent protein.
- Recent advances in delivery of veterinary DNA vaccines against avian pathogens
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