CTLA-4 Ligation Suppresses CD28-induced NF-κB and AP-1 Activity in Mouse T Cell Blasts*
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Summary
It is proposed that the major impact of CTLA-4 ligation is inhibition of signals mediated by CD28, which regulates T cell activation by inhibiting the T cell receptor-mediated signals.
- Type
- dissertation
- Published
- 1999-05-14
- Cited by
- 98
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W10318864
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21009543
Keywords
Humanities, Geology, Art
References
- Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
- CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.
- Regulation of CTLA-4 expression during T cell activation.
- Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.
- Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail (*)
- Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
- Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
- Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions*
- Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
- CTLA-4 can function as a negative regulator of T cell activation.
- B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
- Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
- In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.
- Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
- Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
- The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation.
- Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.
- CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
- NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
- Biased dependency of CD80 versus CD86 in the induction of transcription factors regulating the human IL-2 promoter.
Cited by
- Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
- Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86 1
- Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies
- Contribution à l'étude de l'immunosuppression et de l'induction de tolérance à l'allogreffe induite par des anticorps anti-CD28
- RNA Interference of CTLA4 in Human Leukaemia T Cells
- TGF-β1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD261
- Genetic and immunological control of human myasthenia gravis
- The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes1
- CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
- Signalling of E3 ubiquitin-protein ligases in the regulation of priming and tolerance of T cells
- The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
- Signalling mechanisms underlying priming and tolerance of T cells
- Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
- Role of Mitogen-Activated Protein Kinases in CpG DNA-Mediated IL-10 and IL-12 Production: Central Role of Extracellular Signal-Regulated Kinase in the Negative Feedback Loop of the CpG DNA-Mediated Th1 Response1
- CD28, CTLA‐4 and their ligands: who does what and to whom?
- CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch.
- The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation.
- CTLA‐4 interacts with STAT5 and inhibits STAT5‐mediated transcription
- T-cell regulation by CD28 and CTLA-4
- Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
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