Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
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Summary
It is demonstrated that, in contrast to CTLA-4 germline knockout mice, conditional deletion on T reg cells during adulthood confers protection from EAE and does not increase resistance to tumors.
- Type
- article
- Published
- 2015-09-21
- Cited by
- 211
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W1914215890
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4688867
Keywords
CTLA-4, Cytotoxic T cell, Autoimmunity, Biology, FOXP3
References
- CTLA-4 Ligation Suppresses CD28-induced NF-κB and AP-1 Activity in Mouse T Cell Blasts*
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- IL-10 is critical in the regulation of automimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice
- CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
- In Vitro Treg Suppression Assays
- Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
- CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
- CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.
- A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection1
- Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
- Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
- Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
- Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
- Treg and CTLA-4: Two intertwining pathways to immune tolerance
- T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus
- Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Cited by
- Multi-faceted inhibition of dendritic cell function by CD4+Foxp3+ regulatory T cells.
- CTLA-4 and Autoimmunity: New Twists in the Tale
- Translating Treg Therapy in Humanized Mice
- FOXP3 and CTLA-4 : how isoforms regulate immunological tolerance
- Targeting regulatory T cells in tumors
- Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
- T follicular regulatory cells
- Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma.
- CD28 costimulation: from mechanism to therapy
- Co-stimulatory and co-inhibitory pathways in autoimmunity
- Coinhibitory pathways in the B7-CD28 ligand-receptor family
- CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis
- Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?
- Immune checkpoint-targeted therapy: cancer and autoimmune diseases represent two sides of the same coin
- Regulatory T Cells: Differentiation and Function
- Modulation of Phenotype and Function of Human CD4+CD25+ T Regulatory Lymphocytes Mediated by cAMP-Elevating Agents
- Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells
- Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy
- Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
- EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis.
Related papers
- The role of FOXP3 in autoimmunity.
- Supplementary Figure S6: Ipilimumab does not deplete CD4+CTLA-4+FOXP3+ Tregs from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers
- Supplementary Figure S6: Ipilimumab does not deplete CD4+CTLA-4+FOXP3+ Tregs from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers
- Preferential Expansion of Foxp3+ T Regulatory Cells in CTLA-4–Deficient and CTLA-4–Haploinsufficient C57BL/6 Mice
- FOXP3 and CTLA-4 genetic variants' influence on the susceptibility and clinical course of basal cell carcinoma
- Supplementary Figure S3: Effect of ipilimumab on FOXP3+ cells in human tumors from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers
- Supplementary Figure S3: Effect of ipilimumab on FOXP3+ cells in human tumors from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers
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