Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).
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Summary
Activity was markedly decreased by using the Nedd8-unmodified mutant cullin-1 (K696R), indicating that the modification may play an important role on the SCF(skp2) activity toward p27(kip1), one of the components of SCF.
- Type
- dissertation
- Published
- 2000-04-21
- Cited by
- 138
- References
- 17
- Access
- Open access
- OpenAlex
- https://openalex.org/W10772955
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2907832
Keywords
Carnot cycle, Refrigeration, Refrigerant, Process engineering, Process (computing)
References
- Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
- Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
- p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
- Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
- Covalent modification of all members of human cullin family proteins by NEDD8
- ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
- Identification of NEDD8-conjugation site in human cullin-2.
- Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.
- A new NEDD8-ligating system for cullin-4A.
- SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
- CDK inhibitors: positive and negative regulators of G1-phase progression.
- Cell-Free Degradation of p27kip1, a G1 Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome
- The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
- Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1
- Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.
- Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Cited by
- AXR1-ECR1–Dependent Conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 Is Required for Auxin Response Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010282.
- TIP120A associates with unneddylated cullin 1 and regulates its neddylation
- Structural Basis for the Function of DCN-1 in Protein Neddylation*
- Cell cycle-dependent caspase-like activity that cleaves p27(KIP1) is the beta(1) subunit of the 20S proteasome.
- Natural substrates of the proteasome and their recognition by the ubiquitin system.
- COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN
- Control of cullin-ring ubiquitin ligase activity by nedd8.
- Elucidating the cause of FAT10 over-expression in liver and colon carcinomas
- Triggering ubiquitination of a CDK inhibitor at origins of DNA replication
- NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis.
- Expression, purification, and characterization of the E1 for human NEDD8, the heterodimeric APPBP1-UBA3 complex.
- The characterisation of a novel deubiquitinating enzyme in Escherichia coli
- Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8
- Characterization of a Novel Nuclear Hormone Receptor Coactivator, Uba3, and its Function in Breast Cancer
- Role of the Neddylation Enzyme Uba3, a New Estrogen Receptor Corepressor, in Breast Cancer
- The role of regulated protein degradation in auxin response
- In vitro systems for NEDD8 conjugation by Ubc12.
- Identifikation und Charakterisierung von neuen Interaktionspartnern des CDK-Inhibitors p27Kip1
- Ubiquitin and proteasomes: Themes and variations on ubiquitylation
- The novel protective role of P27 in MLN4924-treated gastric cancer cells
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