Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
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Summary
Results suggest that cyclin G might participate in a p53‐mediated pathway to prevent tumorigenesis.
- Type
- article
- Published
- 1994-10-01
- Cited by
- 481
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1823168351
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2098629
Keywords
Biology, Molecular biology, Cyclin A, Suppressor, Tumor suppressor gene
References
- Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.
- Cell cycle regulated phosphorylation of RPA‐32 occurs within the replication initiation complex.
- cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.
- Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
- p53-mediated cell death: relationship to cell cycle control
- Participation of p53 protein in the cellular response to DNA damage.
- Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle
- Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression
- Premature p34cdc2 activation required for apoptosis.
- Identification of a mouse B‐type cyclin which exhibits developmentally regulated expression in the germ line
- Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
- Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.
- p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.
- Requirement for the replication protein SSB in human DMA excision repair
- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
- Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization.
- Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.
- p53, guardian of the genome
- WAF1, a potential mediator of p53 tumor suppression.
Cited by
- Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
- Apoptosis was promoted at a nonpermissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells.
- Cell cycle-related gene expression in the adult rat brain: selective induction of cyclin G1 and p21WAF1/CIP1 in neurons following focal cerebral ischemia.
- MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
- Alcohol Facilitates HCV RNA Replication Via Up-Regulation of miR-122 Expression and Inhibition of Cyclin G1 in Human Hepatoma Cells
- Lysines in the tetramerization domain of p53 selectively modulate G1 arrest
- Cyclin G: a regulator of the p53-Mdm2 network.
- Integration of the PRB and P53 Cell Cycle Control Pathways
- Molekularer Mechanismus der Stickstoffmonoxid-vermittelten Akkumulation des Tumorsuppressors p53
- Functional consequences of cyclin D1 overexpression in human mammary luminal epithelial cells
- Protein kinase CK2 interacts with a multi-protein binding domain of p53
- Synthesis And Application Of Atp Analogs For Phosphorylation-Dependent Kinase-Substrate Crosslinking
- The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.
- The p53 tumor suppressor gene: structure, function and mechanism of action.
- G1 and S-phase checkpoints, chromosome instability, and cancer.
- Cyclin A/CDK2 regulates multiple G2 phase pathways
- Regulation of cell cycle progression following DNA damage.
- Regulation of p53 downstream genes.
- Altering Presenilin Gene Activity in Zebrafish Embryos Causes Changes in Expression of Genes with Potential Involvement in Alzheimer's Disease Pathogenesis
- An Investigation Of Gene Networks Influenced By Low Dose Ionizing Radiation Using Statistical And Graph Theoretical Algorithms
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