Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
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Summary
Results show that Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation and is two- to threefold more efficient in activating the MAPK and SAPK pathways relative to the wild-type protein.
- Type
- article
- Published
- 1997-03-15
- Cited by
- 142
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W9087424
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37792244
Keywords
Composite material, Materials science, Thermal, Physics, Meteorology
References
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- A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.
Cited by
- Development and application of non-integrating lentiviral vectors for gene therapy
- Transgenic mice as an in vivo model of lymphomagenesis.
- Regulation of HTLV-I oncoprotein Tax by PDLIM2
- Deregulation of NF-κB and its upstream kinases in cancer
- Investigation of the effects of virus integration on host gene expression in mouse tumour samples
- Identificación de nuevas señales extracelulares que median sus actividades biológicas vía Cot/tpl-2
- TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105
- Regulation of cytokines by Tpl-2 in dendritic cells andmacrophages
- In vitro selection of adenine‐dependent ribozyme against Tpl2/Cot oncogene
- p27kif Protein Levels and E2F Activity Are Targets of Cot Kinase During G1 Phase Progression in T Cells1
- A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice.
- Benzo[a]pyrene‐7,8‐diol‐9,10‐epoxide inhibits gap junction intercellular communication via phosphorylation of tumor progression locus 2 in WB‐F344 rat liver epithelial cells
- Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice
- Early changes during acute pancreatitis
- TPL2 signalling: from Toll-like receptors-mediated ERK1/ERK2 activation to Cystic Fibrosis lung disease.
- Retroviral insertional mutagenesis: past, present and future
- Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105.
- Tpl2/Cot Signals Activate ERK, JNK, and NF-κB in a Cell-type and Stimulus-specific Manner*
- Tpl‐2 induces apoptosis by promoting the assembly of protein complexes that contain caspase‐9, the adapter protein Tvl‐1, and procaspase‐3
- MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
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