A template for the protein kinase family.
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Summary
The striking convergence of the structure with the biochemistry and genetics provides for the first time a molecular basis for understanding how this enzyme functions, as well as an explanation for the highly conserved residues that are scattered throughout the molecule.
- Type
- review
- Published
- 1993-03-01
- Cited by
- 197
- References
- 25
- OpenAlex
- https://openalex.org/W1982960071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39360531
Keywords
Protein subunit, Biochemistry, Protein kinase A, Kinase, Enzyme
References
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- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
- Salt-induced conformational changes in the catalytic subunit of adenosine cyclic 3',5'-phosphate dependent protein kinase. Use for establishing a connection between one sulfhydryl group and the gamma-P subsite in the ATP site of this subunit.
- Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with a water-soluble carbodiimide: identification of carboxyl groups protected by MgATP and inhibitor peptides.
- Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
- Adenosine cyclic 3',5'-monophosphate dependent protein kinase: fluorescent affinity labeling of the catalytic subunit from bovine skeletal muscle with o-phthalaldehyde.
- Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Cited by
- Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2
- Structure and Expression of the Caenorhabditis elegans Protein Kinase C2 Gene
- Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
- Intrasteric regulation of protein kinases.
- Evading the interferon response: hepatitis C virus and the interferon-induced protein kinase, PKR.
- Roles of PAK family kinases.
- Investigation of the role of haematopoietic cell kinase in normal and leukaemic haematopoiesis
- Molecular cloning and characterization of a second calcium-dependent protein kinase of Plasmodium falciparum.
- Characterisation of four Drosophila proteins involved in regulation of gene expression.
- Cytoskeleton and Small G Proteins
- Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.
- Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family.
- Structure of the human gene encoding the beta-adrenergic receptor kinase.
- The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle.
- Plasmodium falciparum protein kinase CK2
- Activation of SsoPK4, an Archaeal eIF2α Kinase Homolog, by Oxidized CoA
- Isolation and characterization of a human putative receptor protein kinase cDNA STYK1*
- Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation
- Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor.
- Structural basis for activation of the titin kinase domain during myofibrillogenesis
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