Tissue-specific and insulin-dependent expression of a pancreatic amylase gene in transgenic mice
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Summary
A murine pancreatic amylase gene, Amy-2.2y, is characterized, whose promoter sequence is 30% divergent from those of previously sequenced amyl enzyme genes, and which contains the sequences required for tissue-specific and hormonally regulated expression.
- Type
- article
- Published
- 1987-01-01
- Cited by
- 59
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1946050661
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36639926
Keywords
Biology, Minigene, Gene, Regulatory sequence, Transgene
References
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- Independent regulation of nonallelic pancreatic amylase genes in diabetic mice.
- Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose.
- Structure of the two related elastase genes expressed in the rat pancreas.
- Effects of insulin on messenger RNA activities in rat liver.
- Genetic determination of amylase synthesis in the mouse.
- Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene.
- Nucleotide sequences required for the regulation of a rat alpha 2u-globulin gene by glucocorticoids
- Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells
- Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene
- Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
- The evolution of genes: the chicken preproinsulin gene.
- EFFECT OF INSULIN ON PANCREATIC AMYLASE AND CHYMOTRYPSINOGEN.
- Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice.
- Glucocorticoids increase amylase mRNA levels, secretory organelles, and secretion in pancreatic acinar AR42J cells
- Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.
- Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
- Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
- Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding.
- Microsurgically produced homozygous-diploid uniparental mice.
Cited by
- Effects of Diabetes and Insulin on α-amylase Messenger RNA Levels in Rat Parotid Glands
- The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice
- Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
- The islet-acinar axis of the pancreas
- Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development
- Insulin response of a hybrid amylase/CAT gene in transgenic mice.
- Glucocorticoid and developmental regulation of amylase mRNAs in mouse liver cells
- Retroviral and pseudogene insertion sites reveal the lineage of human salivary and pancreatic amylase genes from a single gene during primate evolution
- Potentiating effect of insulin on exocrine secretory function in isolated rat pancreatic acini.
- Concerted evolution of human amylase genes
- PEPCK Gene as Model of Inhibitory Effects of Insulin on Gene Transcription
- Molecular aspects of enzyme synthesis in the exocrine pancreas with emphasis on development and nutritional regulation
- Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats
- Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.
- Multiple insulin-responsive elements regulate transcription of the GAPDH gene.
- Effect of chronic hyperghrelinemia on ingestive action of ghrelin.
- Insulin-mediated regulation of tyrosine aminotransferase in rat hepatoma cells: inhibition of transcription and inhibition of enzyme degradation.
- Pancreatic acinar cell amylase gene expression: selective effects of adrenalectomy and corticosterone replacement.
- Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
- An amylase/cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas
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