Droloxifene (3-hydroxytamoxifen) has membrane antioxidant ability: potential relevance to its mechanism of therapeutic action in breast cancer.

Keywords

Lipid peroxidation, Liposome, Phospholipid, Antioxidant, Chemistry

References

• The structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent.Douglas B. Swift, Jennifer Reeves — 1992
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Cited by

• Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison with liver microsomes and potential relevance to the cardiovascular benefits associated with cancer prevention and treatment by tamoxifen.Helen Wiseman, Michael Cannon, H. R. V. Arnstein — 1993
• Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances.Helen Wiseman — 1994
• Chronic effects of toremifene on the vasculature of menopause-induced rats.Jorge L. González‐Pérez — 2003
• Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer actionHelen Wiseman — 1993
• Enhancement by tamoxifen of the membrane antioxidant action of the yeast membrane sterol ergosterol: relevance to the antiyeast and anticancer action of tamoxifen.Helen Wiseman, Michael Cannon, H. R. V. Arnstein — 1993
• Non-esterified Cholesterol Content of Lysosomes Modulates Susceptibility to Oxidant-induced PermeabilizationJohn J. Reiners, Miriam Kleinman, David Kessel — 2010
• The Potential of SERMs for Reducing the Risk of Coronary Heart Disease.Elizabeth Barrett‐Connor, David A. Cox, Pamela W. Anderson — 1999
• The antioxidant action of a pure antioestrogen: ability to inhibit lipid peroxidation compared to tamoxifen and 17 beta-oestradiol and relevance to its anticancer potential.Helen Wiseman — 1994
• Effects of tamoxifen, droloxifene and 17 beta-estradiol on Rauscher mouse leukemogenesis.G Sydow, V. Wunderlich — 1994
• Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assaySheng Tong, Qing Chen, Siqing Shan — 2006
• Effect of anti-inflammatory drugs on splenocyte membrane fluidity.Helena Ferreira, Marlene Lúcio, José L. F. C. Lima — 2005
• Estrogens, progestins, selective estrogen receptor modulators, and the arterial tree.Robert A. Wild, Steven E. Reís — 2001
• Tamoxifen and estrogens as membrane antioxidants: comparison with cholesterol.Helen Wiseman — 1994
• Revisiting the Effect of 3 Sesquiterpenoids From Conocephalum conicum (Snake Liverwort) on Rat Spleen Lymphocyte Viability and Membrane FunctioningSonja Filipović, Nikola M. Stojanović, Katarina Mitić — 2022
• Membrane Antioxidant-Mediated Cardioprotective Anticarcinogenic Actions of TamoxifenH. Wiseman — 1996
• Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMsM. Díaz, J. Marrero-Alonso, B. G. Marrero — 2006

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