Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats.
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Summary
Tamoxifen reduces brain injury in the neonatal rat and is neuroprotective in adult rats.
- Type
- article
- Published
- 2004-01-19
- Cited by
- 46
- References
- 70
- OpenAlex
- https://openalex.org/W2021759638
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29268282
Keywords
Tamoxifen, Neuroprotection, Hypoxia (environmental), Medicine, Endocrinology
References
- The structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent.
- [Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil--detection of hydroxyl radicals with salicylic acid].
- Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex.
- Mechanisms of tamoxifen-induced apoptosis
- Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat
- Inhibition of volume-activated I- and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition.
- Tamoxifen and Breast Cancer
- Microsomal lipid peroxidation.
- A permanently charged tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.
- Neurology of the newborn.
- Ca2(+)-dependent binding of tamoxifen to calmodulin isolated from bovine brain.
- NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.
- Modulation of Estrogen Receptor α Function and Stability by Tamoxifen and a Critical Amino Acid (Asp-538) in Helix 12*
- Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury.
- Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.
- Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion
- Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
- Effects of tamoxifen on cardiovascular risk factors in postmenopausal women.
- The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation
- Protective action of 17β‐estradiol and tamoxifen on glutamate toxicity in glial cells
Cited by
- Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model.
- The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
- The effects of tamoxifen on learning, memory and brain tissues oxidative damage in ovariectomized and naïve female rats
- Tamoxifen as an effective neuroprotectant in an endovascular canine model of stroke.
- Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.
- Tamoxifen reduces infiltration of inflammatory cells, apoptosis and inhibits IKK/NF-kB pathway after spinal cord injury in rats
- Apoptosis and necrosis in developing cerebellum and brainstem induced after focal cerebral hypoxic-ischemic injury.
- Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats
- Tamoxifen attenuates inflammatory‐mediated damage and improves functional outcome after spinal cord injury in rats
- Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment
- Neuroprotective Effects of Vascular Endothelial Growth Factor Following Hypoxic Ischemic Brain Injury in Neonatal Rats
- Effects of Dizocilpine (MK-801) via Up-modulation of N-methyl-D-aspartate (NMDA) Receptors on Hypoxic-Ischemic Brain Injury in Neonatal Rats
- The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
- Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling
- Dexamethasone-induced neuroprotection in hypoxic-ischemic brain injury in newborn rats is partly mediated via Akt activation.
- Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia.
- Tamoxifen modulates apoptosis in multiple modes of action in CreER mice
- Grape seed extract suppresses lipid peroxidation and reduces hypoxic ischemic brain injury in neonatal rats.
- Estrogen attenuates hypoxic-ischemic brain injury in neonatal rats.
- Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen.
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