Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
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Summary
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with an IC50 value of 2.7 nM.
- Type
- article
- Published
- 1986-03-13
- Cited by
- 2,315
- References
- 14
- OpenAlex
- https://openalex.org/W1589866689
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45131548
Keywords
Staurosporine, Protein kinase C, Protein kinase inhibitor, IC50, Protein kinase A
References
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- Phospholipid-sensitive calcium-dependent protein kinase: inhibition by antipsychotic drugs.
- Activation of protein kinase C by non-phorbol tumor promoter, mezerein.
- The role of protein kinase C in cell surface signal transduction and tumour promotion
- Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase.
- Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.
- Widespread occurrence of calcium-activated, phospholipid-dependent protein kinase in mammalian tissues.
- Tetrocarcins, new antitumor antibiotics. 3. Antitumor activity of tetrocarcin A.
- A role of membranes in the activation of a new multifunctional protein kinase system.
- Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.
- A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.
Cited by
- Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide.
- Endocytosis is regulated by protein kinase A, but not protein kinase C in a secretory epithelial cell line.
- PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments.
- Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
- Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
- Contrasting effects of sn-1,2-dioctanoyl glycerol as compared to other protein kinase C activators in adrenal glomerulosa cells.
- Platelet coagulation factor Va: the major secretory platelet phosphoprotein.
- Further studies on the involvement of protein kinase C in human sperm flagellar motility.
- Chelerythrine is a potent and specific inhibitor of protein kinase C.
- Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+.
- Activation of protein kinase C inhibits ATP‐induced [Ca2+]i elevation in rat osteoblastic cells: Selective effects on P2Y and P2U signaling pathways
- Potentiation by cholesterol and vitamin D3 oxygenated derivatives of arachidonic acid release and prostaglandin E2 synthesis induced by the epidermal growth factor in NRK 49F cells: the role of protein kinase C.
- Fusarium merismoides Corda NR 6356, the source of the protein kinase C inhibitor, azepinostatin. Taxonomy, yield improvement, fermentation and biological activity.
- Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors.
- Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells.
- Mechanism and regulation of swelling-activated inositol efflux in brain glial cells.
- Accelerated desensitization of nicotinic receptor channels and its dependence on extracellular calcium in isolated skeletal muscles of streptozotocin‐diabetic mice
- View of K+ secretion through the apical K channel of cortical collecting duct.
- Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation.
- Cellular mechanisms mediating rat renal microvascular constriction by angiotensin II.
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