Mutations in Structural Genes of the Mitochondrial Complex IV May Influence Breast Cancer
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Summary
An in silico investigation of mutations in structural genes of Complex IV of OXPHOS shows four variants with significant pathogenic potential and highlights nine genes with a potential impact on BC.
- Type
- article
- Published
- 2023-07-01
- Cited by
- 19
- References
- 96
- Access
- Open access
- OpenAlex
- https://openalex.org/W4384827357
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:260032151
Keywords
Oxidative phosphorylation, Gene, In silico, Cytochrome c oxidase, Biology
References
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- Spatial Distribution of Cellular Function: The Partitioning of Proteins between Mitochondria and the Nucleus in MCF7 Breast Cancer Cells
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- Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9.
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- The Metabolism of Carcinoma Cells
- The clonal and mutational evolution spectrum of primary triple negative breast cancers
Cited by
- Mitochondrial bioenergetics of breast cancer.
- Mitochondrial genomic alterations in cholangiocarcinoma cell lines
- Differential gene expression analysis supports dysregulation of mitochondrial activity as a new perspective for glioblastoma's aggressiveness
- Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer
- STMGraph: spatial-context-aware of transcriptomes via a dual-remasked dynamic graph attention model
- Five Key Criteria for Identifying Optimal Therapeutic Targets in Protein‐Mediated Diseases
- GeNetFormer: Transformer-Based Framework for Gene Expression Prediction in Breast Cancer
- Mitochondrial genomic alterations in cholangiocarcinoma cell lines
- A novel multislice framework for precision 3D spatial domain reconstruction and disease pathology analysis
- Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.
- Computational analysis of missense variants in MT-ND1 and MT-CO2 associated with breast cancer: A functional and structural impact
- Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress
- Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients
- Mitochondrial DNA mutations and intercellular mitochondrial transfer in cancer: mechanisms, biological effects, and clinical potential
- Identification of mitochondrial-related subtypes and development of a prognostic model for pancreatic ductal adenocarcinoma
- Differential Gene Expression Analysis Supports Dysregulation of Mitochondrial Activity as a New Perspective for Glioblastoma's Aggressiveness
- Differential Gene Expression Analysis Supports Dysregulation of Mitochondrial Activity as a New Perspective for Glioblastoma's Aggressiveness
- Mo-CBP3-PepIII Changes the Proteomic Profile of Gastric Cancer Cells, Induces Membrane Pore Formation, and ROS Overaccumulation
- Mitochondrial genome aberrations in canine spleen tumours
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