LOXL2 small molecule inhibitor restrains malignant transformation of cervical cancer cells by repressing LOXL2-induced epithelial-mesenchymal transition (EMT)
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Summary
LOXL2 may be a promising diagnostic and therapeutic biomarker for cervical cancer, and its small molecule inhibitor may be an effective anti-tumor drug.
- Type
- article
- Published
- 2022-05-04
- Cited by
- 21
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W4229042177
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:248527128
Keywords
Lysyl oxidase, Epithelial–mesenchymal transition, Cancer research, Carcinogenesis, Biology
References
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- ONCOMINE: a cancer microarray database and integrated data-mining platform.
- T Lymphocyte Regulation of Lysyl Oxidase in Diet-Induced Cardiac Fibrosis
- Lysyl oxidase‐like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors
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- Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.
- Human Copper-Dependent Amine Oxidases
- Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
Cited by
- Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics
- Genomic analysis of cervical carcinoma identifies Alpelisib as a therapeutic option for PIK3CA‐mutant cervical carcinoma via the PI3K/AKT pathway
- LOXL2 promotes tumor proliferation and metastasis by FAK/Src signaling in esophageal squamous cell carcinoma
- LOXL2 in Cancer: A Two-Decade Perspective
- Increased LOXL2 expression is related to poor prognosis in lung squamous cell carcinoma
- Three-dimensional chromatin analysis reveals Sp1 as a mediator to program and reprogram HPV-host epigenetic architecture in cervical cancer.
- The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis
- Serum LOXL2 is Elevated and an Independent Biomarker in Patients with Coronary Artery Disease
- β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis
- The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells
- Bone marrow microenvironment-targeted yolk-shell nanoparticle enhances acute myeloid leukemia chemotherapy by preventing endothelial cell/ECM-mediated adhesion
- Revisiting Treatment Strategies: Addressing Epithelial-to-Mesenchymal Transition-Induced Resistance in Hepatocellular Carcinoma
- Dihydroartemisinin Suppresses LOXL2‐Mediated Glycerophospholipid Metabolic Reprogramming to Induce Cuproptosis in Colorectal Cancer Cells
- Pathways to precision medicine in cervical cancer: a comprehensive review of small molecule inhibitors, biomarkers and computational approaches
- Lung endothelial PEAR1 induces tumor cell dormancy
- The role of the LOX family in cancer.
- A PBN-RL-XAI Framework for Discovering a “Hit-And-Run” Therapeutic Strategy in Melanoma
- Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma
- From Virtual Screening to Cell Phenotype: 4‐Thiazolidone Scaffolds Targeting LOXL2 in Breast Cancer
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