Lysyl oxidase‐like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors
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Summary
It is determined that the methylation status of the 1150 bp 5′ CpG island may contribute to the regulation of the gene, and this results suggest that increased LOXL2 expression in colon and esophageal cancer might contribute to tumor progression.
- Type
- article
- Published
- 2007-07-01
- Cited by
- 115
- References
- 64
- OpenAlex
- https://openalex.org/W1984626069
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37134264
Keywords
Lysyl oxidase, Cancer research, Biology, Pathology, Stromal cell
References
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- The role of lysyl oxidase and collagen crosslinking during sea urchin development.
- Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues
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- Deletion mapping of the tumor suppressor locus involved in colorectal cancer on chromosome band 8p21
Cited by
- LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
- Somatic Copy Number Mosaicism Contributes to Genomic Diversity in Mus musculus
- A general protease digestion procedure for optimal protein sequence coverage and PTM analysis of recombinant glycoproteins: Application to the characterization of hLOXL2 glycosylation
- Interaction of lysyl oxidase with the hormone placental lactogen and its effecton mammary epithelial cell proliferation and migration
- Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
- Differential expression of the LOX family genes in human colorectal adenocarcinomas.
- Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
- New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease*
- Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities
- Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer
- Human Lysyl Oxidase-like 2
- LOXL2 in epithelial cell plasticity and tumor progression.
- The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin
- Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor
- Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
- Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level
- Functional analysis of LOXL2 in pancreatic carcinoma
- Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes.
- Evaluation of serum lysyl oxidase as a blood test for colorectal cancer
- Lysyl oxidase in colorectal cancer.
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