Gadolinium chloride pre-treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis
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Summary
In CLP sepsis model rats treated with GdCl3, the release of systemic and intestinal pro-inflammatory factors was reduced and tissue damage was alleviated when compared with untreated CLP rats, and it was demonstrated to reduce cell apoptosis through the inhibition of caspase-3 expression.
- Type
- article
- Published
- 2021-08-09
- Cited by
- 2
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W3192579758
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:237454321
Keywords
Occludin, Sepsis, Barrier function, Western blot, Tumor necrosis factor alpha
References
- Early caspase‐3 activation independent of apoptosis is required for cellular function
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- Kupffer cell depletion by gadolinium chloride aggravates liver injury after brain death in rats
- CASPASE CONTROL: PROTAGONISTS OF CANCER CELL APOPTOSIS
- Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles
- Protective effect of sodium tanshinone IIA sulfonate on injury of small intestine in rats with sepsis and its mechanism
- Role of Kupffer cells in pathogenesis of sepsis‐induced drug metabolizing dysfunction
- Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase‐3
- Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats
- Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View
- Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury
- MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
- Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation
- The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier.
- Protective effect of rhBNP on intestinal injury in the canine models of sepsis.
- Intestine-Specific Mttp Deletion Decreases Mortality and Prevents Sepsis-Induced Intestinal Injury in a Murine Model of Pseudomonas aeruginosa Pneumonia
- GADOLINIUM CHLORIDE ALTERS THE ACINAR DISTRIBUTION OF PHAGOCYTOSIS AND BALANCE BETWEEN PRO- AND ANTI‐INFLAMMATORY CYTOKINES
- Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsis.
- Effect of Glutamine on Caspase-3 mRNA and Protein Expression in the Myocardium of Rats With Sepsis
- Physiology and function of the tight junction.
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