Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeability.
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Summary
The data suggest that IL-18 may potentiate inflammation in the context of IBD by facilitating neutrophil transepithelial migration via MLCK-dependent disruption of tight junctional occludin.
- Type
- article
- Published
- 2012-02-01
- Cited by
- 42
- References
- 65
- OpenAlex
- https://openalex.org/W2112483272
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26508395
Keywords
Occludin, Myosin light-chain kinase, Tight junction, Barrier function, Paracellular transport
References
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- Interactions of neutrophils with epithelial cells: lessons from the intestine.
- Occludin is a functional component of the tight junction.
- Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions
- Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability1
- In Vivo Pattern of Lipopolysaccharide and Anti-CD3-Induced NF-κB Activation Using a Novel Gene-Targeted Enhanced GFP Reporter Gene Mouse1
- Protein Interactions at the Tight Junction
- Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
- Occludin Modulates Transepithelial Migration of Neutrophils*
- Pathogen recognition and innate immunity.
- Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B.
- Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
- E-cadherin expression in intestinal epithelium.
Cited by
- Giardia duodenalis Cathepsin B Proteases Degrade Intestinal Epithelial Interleukin-8 and Attenuate Interleukin-8-Induced Neutrophil Chemotaxis
- CD24 activates the NLRP3 inflammasome through c-Src kinase activity in a model of the lining epithelium of inflamed periodontal tissues
- The Mammalian Blood-Testis Barrier: Its Biology and Regulation.
- The role of intestinal epithelial barrier function in the development of NEC
- CD4(+) T cells from food allergy model are resistant to TCR-dependent apoptotic induction.
- Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1
- Inflammation promotes a cytokine response and disrupts the cervical epithelial barrier: a possible mechanism of premature cervical remodeling and preterm birth.
- T1777 Hepatocyte Growth Factor Stimulates the Migration of Gastric Epithelial Cells by Altering the Intracellular Localization of the Tight Junction Protein ZO-1
- Intestinal barrier dysfunction triggered by invasive bacteria.
- Leukocyte–Epithelial Interactions and Mucosal Homeostasis
- The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs—disulfiram and ritonavir
- Epithelial Immunomodulation by Giardia
- Bifidobacterium lactis 420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells.
- Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease
- PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease.
- Pathogenesis of NEC: Role of the Innate and Adaptive Immune Response
- The role of the Coxsackie and Adenoviral Receptor in TNF alpha driven inflammation
- Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms.
- Is nitric oxide an essential mediator in cervical inflammation and preterm birth?
- Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome
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