Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis
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Summary
It is demonstrated that deletion of MLCK improves survival following sepsis, associated with normalization of intestinal permeability and selected tight junction proteins.
- Type
- article
- Published
- 2017-06-07
- Cited by
- 49
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W28598488
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21346974
Keywords
Political science
References
- 1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway
- Endogenous IL-10 protects mice from death during septic peritonitis.
- Myosin light chain kinase: pulling the strings of epithelial tight junction function
- Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction
- Tight junctions on the move: molecular mechanisms for epithelial barrier regulation
- MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
- Inhibition of IKKß in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality
- Sepsis Enhances Epithelial Permeability with Stretch in an Actin Dependent Manner
- Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis
- Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability.
- Intestine-Specific Deletion of Microsomal Triglyceride Transfer Protein Increases Mortality in Aged Mice
- Epidermal growth factor improves survival and prevents intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia
- Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
- INTESTINAL CROSSTALK: A NEW PARADIGM FOR UNDERSTANDING THE GUT AS THE "MOTOR" OF CRITICAL ILLNESS
- Influence of the critically ill state on host-pathogen interactions within the intestine: Gut-derived sepsis redefined
- The role of caspase-3 in lipopolysaccharide-mediated disruption of intestinal epithelial tight junctions.
- Disruption of tight junctions during polymicrobial sepsis in vivo
- Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness
- INTESTINE-SPECIFIC OVEREXPRESSION OF IL-10 IMPROVES SURVIVAL IN POLYMICROBIAL SEPSIS
- Intestinal permeability defects: Is it time to treat?
Cited by
- Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?
- Honokiol increases CD4+ T cell activation and decreases TNF but fails to improve survival following sepsis
- Regulators of intestinal epithelial migration in sepsis
- Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease
- A venomous relationship: Inflammation, the gut barrier and the STING pathway
- Gut integrity in critical illness
- Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
- Gut Luminal and Clinical Benefits of Early Enteral Nutrition in Shock
- Overexpression of Bcl-2 in the intestinal epithelium prevents sepsis-induced gut barrier function via altering tight junction protein expression
- Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis
- Potential of glucocorticoids to treat intestinal inflammation during sepsis.
- Ageing, metabolism and the intestine
- Accumulation of milk increases the width of tight junctions in the epithelium of mouse mammary alveoli
- Gut-liver crosstalk in sepsis-induced liver injury
- Membrane permeant inhibitor of myosin light chain kinase worsens survival in murine polymicrobial sepsis
- Measurement of intestinal permeability during sepsis
- Gadolinium chloride pre-treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis
- Crosstalk between gut microbiota and sepsis
- Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
- Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis
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