Tumor-infiltrating lymphocytes and POLE mutation in endometrial carcinoma.
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Summary
TIL-high pattern shows a moderate accuracy in distinguishing POLE-mutated fromPOLE-wild-type ECs after the exclusion of MMR-deficient cases, and might be considered in an integrate algorithm to identify POLE -mutated ECs when sequencing is unavailable.
- Type
- review
- Published
- 2021-03-12
- Cited by
- 35
- References
- 39
- OpenAlex
- https://openalex.org/W3136725767
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:232229956
Keywords
Medicine, Area under the curve, Mutant, Diagnostic odds ratio, Wild type
References
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- A clinically applicable molecular-based classification for endometrial cancers
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- Histotype-Genotype Correlation in 36 High-grade Endometrial Carcinomas
- Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative
- Circulating MicroRNAs as a Novel Class of Diagnostic Biomarkers in Gastrointestinal Tumors Detection: A Meta-Analysis Based on 42 Articles
- Synthesizing Evidence from Diagnostic Accuracy TEsts: the SEDATE guideline
- POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
- Cancer statistics, 2015
- Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
- Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer.
- Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro
- Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
- Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancer
- Blinded histopathological characterisation of POLE exonuclease domain‐mutant endometrial cancers: sheep in wolf's clothing
- Assessing tumor infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno-Oncology Biomarkers Working Group
- Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series
- Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
Cited by
- Mismatch repair-deficiency specifically predicts recurrence of atypical endometrial hyperplasia and early endometrial carcinoma after conservative treatment: A multi-center study.
- Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer
- Identification of Distinct Molecular Subtypes of Endometrioid Adenocarcinoma
- miRNAs in the Expression Regulation of Dopamine-Related Genes and Proteins in Endometrial Cancer
- Molecular Profiling of Endometrial Cancer: An Exploratory Study in Aotearoa, New Zealand
- Recent Multiomics Approaches in Endometrial Cancer
- Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity
- EZH2 and Endometrial Cancer Development: Insights from a Mouse Model
- Inquiry and Endometrial-Online computer program: 27 years of clinical registry for endometrial cancer at the University Medical Centre Maribor
- The evolving role of morphology in endometrial cancer diagnostics: From histopathology and molecular testing towards integrative data analysis by deep learning
- Laparoscopic entry techniques: Which should you prefer?
- Is preoperative ultrasound tumor size a prognostic factor in endometrial carcinoma patients?
- Immunohistochemical Markers and TILs Evaluation for Endometrial Carcinoma
- High Tumor Infiltrating Lymphocytes Are Associated with Overall Survival and Good Prognostic Parameters in Endometrial Endometrioid Carcinoma Patients
- Impact of immune infiltration signatures on prognosis in endometrial carcinoma is dependent on the underlying molecular subtype
- Spatial distribution of CD3- and CD8-positive lymphocytes as pretest for POLE wild-type in molecular subgroups of endometrial carcinoma
- The influence of selected microRNAs on the expression profile of genes and proteins related to the tumor necrosis factor-alpha signaling pathways in endometrioid endometrial cancer
- The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
- Specific Pathology Features Enrich Selection of Endometrial Carcinomas for POLE Testing
- The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review
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