Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.
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Summary
Polymerase e-mutated and MSI ECs are associated with high neoantigen loads and number of TILs, which is counterbalanced by overexpression of PD-1 and PD-L1, which may be excellent candidates forPD-1-targeted immunotherapies.
- Type
- article
- Published
- 2015-12-01
- Cited by
- 635
- References
- 16
- Access
- Open access
- OpenAlex
- https://openalex.org/W1759669640
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205126541
Keywords
Microsatellite instability, Tumor-infiltrating lymphocytes, Medicine, Endometrial cancer, Immune checkpoint
References
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- Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
- Discovery and saturation analysis of cancer genes across 21 tumor types
- Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class
- Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
- NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence
- Molecular Pathways Molecular Pathways : Coexpression of Immune Checkpoint Molecules : Signaling Pathways and Implications for Cancer Immunotherapy
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- Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells
- Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies
- T cell-inflamed phenotype and increased Foxp3 expression in infiltrating T-cells of mismatch-repair deficient endometrial cancers
- Expression of immune checkpoint molecules in endometrial carcinoma.
- The Use of Superlatives in Cancer Research.
- [Nivolumab, a new hope in non-small cell lung cancer].
- A panoply of errors: polymerase proofreading domain mutations in cancer
- Neoepitopes and CD3-Positive and CD8-Positive Cells in Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers.
- New Targeted Agents in Endometrial Cancer: Are We Really Making Progress?
- Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer
- Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment
- Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
- Leveraging Immunotherapy for the treatment of Gynecologic Cancers in the Era of Precision Medicine
- Endometrial cancer-targeted therapies myth or reality? Review of current targeted treatments.
- Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance
- Immune Checkpoint Inhibitors in the Treatment of Gynecologic Malignancies
- Frequent PD-L1 expression in primary and metastatic penile squamous cell carcinoma: potential opportunities for immunotherapeutic approaches.
- Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines
- Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
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