A clinically applicable molecular-based classification for endometrial cancers
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Summary
Molecular classification of ECs can be achieved using clinically applicable methods on formalin-fixed paraffin-embedded samples, and provides independent prognostic information beyond established risk factors, and has potential in guiding treatment for individuals with endometrial carcinoma and in stratifying cases in future clinical trials.
- Type
- article
- Published
- 2015-06-30
- Cited by
- 884
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1565078991
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15604292
Keywords
Oncology, Internal medicine, Endometrial cancer, Survival analysis, Immunohistochemistry
References
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- A note on quantifying follow-up in studies of failure time.
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- Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas.
- Just how accurate are the major risk stratification systems for early-stage endometrial cancer?
- Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial
- Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations
- Poor Interobserver Reproducibility in the Diagnosis of High-grade Endometrial Carcinoma
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- Histotype-Genotype Correlation in 36 High-grade Endometrial Carcinomas
- Clinical and pathological characterization of endometrial cancer in young women: identification of a cohort without classical risk factors.
- Diagnostic plots to reveal functional form for covariates in multiplicative intensity models.
- A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Cited by
- Stratification of endometrioid endometrial cancer patients into risk levels using somatic mutations
- Molecular analysis of mixed endometrial carcinomas shows clonality in most cases
- Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy
- Update on pathology, staging and molecular pathology of endometrial (uterine corpus) adenocarcinoma.
- Practical issues in the diagnosis of serous carcinoma of the endometrium
- The more tumors change, the more they stay tame: do T cells keep POLE ultramutated endometrial carcinomas in check?
- Insulinemia, heterogeneity of obesity and the risk of different types of endometrial cancer: existing evidence
- Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis
- A panoply of errors: polymerase proofreading domain mutations in cancer
- Rare cancers: a sea of opportunity.
- Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival
- Hormones and endometrial carcinogenesis
- Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer
- Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
- Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.
- Progesterone receptor expression is associated with longer overall survival within high-grade histotypes of endometrial carcinoma: A Canadian high risk endometrial cancer consortium (CHREC) study.
- Immunohistochemical Profiling of Endometrial Serous Carcinoma
- Endometrial cancer: Not your grandmother's cancer
- Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide treatment
- Molecular genetic heterogeneity in undifferentiated endometrial carcinomas
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