Gene regulation by long non-coding RNAs and its biological functions
Explore this paper's citation graph
Summary
Tissue-specific and condition-specific expression patterns suggest that lncRNAs are potential biomarkers and provide a rationale to target them clinically, and the mechanisms of lncRNA biogenesis, localization and functions in transcriptional, post-transcriptional and other modes of gene regulation, and their potential therapeutic applications are discussed.
- Type
- review
- Published
- 2020-12-22
- Cited by
- 4,123
- References
- 323
- Access
- Open access
- OpenAlex
- https://openalex.org/W3115880421
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:229349783
Keywords
Biology, Biogenesis, Chromatin, Gene, Regulation of gene expression
References
- Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs
- A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival
- The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3
- The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome
- DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination
- Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.
- Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters
- Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species
- MYC regulates the non-coding transcriptome
- Genome engineering using CRISPR-Cas9 system.
- MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation.
- A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
- Synergistic and tunable human gene activation by combinations of synthetic transcription factors
- A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
- Transcription Regulation by the Noncoding RNA SRG1 Requires Spt2-Dependent Chromatin Deposition in the Wake of RNA Polymerase II
- Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks
- Current progress on aptamer-targeted oligonucleotide therapeutics
- PVT1 dependence in cancer with MYC copy-number increase
Cited by
- Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders
- LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1.
- The Dynamics and Plasticity of Epigenetics in Diabetic Kidney Disease: Therapeutic Applications Vis-à-Vis
- Adaptation to seasonal reproduction and temperature-associated factors drive temporal and spatial differentiation in northwest Atlantic herring despite gene flow
- Sex-Specific Development in Haplodiploid Honeybee Is Controlled by the Female-Embryo-Specific Activation of Thousands of Intronic LncRNAs
- LncRNA expression profile during autophagy and Malat1 function in macrophages
- Functional annotation of human long noncoding RNAs using chromatin conformation data
- Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy (Review).
- Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma
- Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications.
- Epigenetic regulation of gene expression in response to environmental exposures: From bench to model
- Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia
- Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers
- RNA-Centric Approaches to Profile the RNA–Protein Interaction Landscape on Selected RNAs
- Polysomal mRNA Association and Gene Expression in Trypanosoma brucei
- Noncoding RNAs and Deep Learning Neural Network Discriminate Multi-Cancer Types
- The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
- Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/β-catenin pathway
- Identification of IFN-β Associated Genes Signature Predicting Overall Survival for Glioblastoma
- Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message
Related papers
- Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate
- Regulation of ribosome biogenesis within the nucleolus
- Nucleolar stress and sugar response in plants
- A review from biological mapping to computation-based subcellular localization
- Critical role for nucleostemin in protein synthesis and muscle cell differentiation
- Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer
- A new PICTure of nucleolar stress
- Iron-Sulfur Protein Assembly in Human Cells.
- 36 Identification and characterization of small subunit ribosomal intermediates
- Differential transcript accumulation and subcellular localization of Arabidopsis ribosomal proteins.