Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
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Summary
Cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B0AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein of SARS-CoV-2 are presented, providing important insights into the molecular basis for coronavirus recognition and infection.
- Type
- article
- Published
- 2020-03-04
- Cited by
- 4,545
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W3010441732
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:212418543
Keywords
Coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Angiotensin-converting enzyme 2, Extracellular, Angstrom
References
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- Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles: Evidence for Upregulation of the Angiotensin-Converting Enzyme Homologue ACE2
- Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder*
- ACE2: a new target for cardiovascular disease therapeutics.
- Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor
- X-ray structure of the dopamine transporter in complex with tricyclic antidepressant
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- A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
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- Collectrin, a Collecting Duct-specific Transmembrane Glycoprotein, Is a Novel Homolog of ACE2 and Is Developmentally Regulated in Embryonic Kidneys*
- A Bayesian View on Cryo-EM Structure Determination
- Angiotensin-converting enzyme 2 is an essential regulator of heart function
- Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
- ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
Cited by
- A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein
- SARS-CoV-2 Infection and Cardioncology: From Cardiometabolic Risk Factors to Outcomes in Cancer Patients
- Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective
- SARS-CoV-2 Delta Variant is Recognized Through GRP78 Host-Cell Surface Receptor, In Silico Perspective
- Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target
- Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
- Evidence for Gastrointestinal Infection of SARS-CoV-2
- scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells
- SARS-CoV-2 receptor ACE2 and TMPRSS2 are predominantly expressed in a transient secretory cell type in subsegmental bronchial branches
- Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics
- The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2
- Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
- Potential neutralizing antibodies discovered for novel corona virus using machine learning
- SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
- A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019‐nCoV)
- Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
- Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection
- Characterization of the SARS-CoV-2 Spike in an Early Prefusion Conformation
- Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics
- The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections
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