What is new in the landscape of insulin-sensitizing agents for polycystic ovary syndrome treatment
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Summary
An overview of the possible role of insulin-sensitizing agents in the treatment of polycystic ovary syndrome encompasses metformin, thiazolidinediones, inositols, alpha-lipoic acid, and GLP1-R analogues.
- Type
- review
- Published
- 2020-01-01
- Cited by
- 15
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W3008868958
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:213927880
Keywords
Polycystic ovary, Hyperinsulinemia, Insulin resistance, Metformin, Anovulation
References
- Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
- Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes
- Lipoic acid - the drug of the future?
- Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta‐analysis
- The rationale of the myo‐inositol and D‐chiro‐inositol combined treatment for polycystic ovary syndrome
- Short-term intervention with liraglutide improved eating behavior in obese women with polycystic ovary syndrome
- Vitamin B12 Status in Metformin Treated Patients: Systematic Review
- Emerging Concepts About Prenatal Genesis, Aberrant Metabolism and Treatment Paradigms in Polycystic Ovary Syndrome
- Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.
- Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
- Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.
- The metabolic status modulates the effect of metformin on the antimullerian hormone-androgens-insulin interplay in obese women with polycystic ovary syndrome.
- Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism.
- Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.
- Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome.
- d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS
- Effects of Thiazolidinediones on Polycystic Ovary Syndrome: a Meta-analysis of Randomized Placebo-Controlled Trials
- Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
- Metformin and Other Insulin Sensitizers in Polycystic Ovary Syndrome
- Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population‐based study
Cited by
- Pharmacological Approaches to Controlling Cardiometabolic Risk in Women with PCOS
- Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
- The Current and Potential Therapeutic Use of Metformin—The Good Old Drug
- Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, open‐label, noninferiority trial
- Adipose tissue and ovarian aging: potential mechanism and protective strategies.
- Quercetin and polycystic ovary syndrome
- The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis
- The effect of alpha-lipoic acid supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in individuals with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials
- GLP-1 and Body Weight: A Scientometric Analysis About How to Select the Best Articles Containing Pharmacological Treatment Methods
- Correção da Resistência à Insulina com o Uso do Mio-inositol na Síndrome do Ovário Policístico
- THE MULTIFACETED APPROACH TO POLYCYSTIC OVARIAN SYNDROME: A REVIEW OF TRADITIONAL AND ALLOPATHIC MEDICINE
- Mechanistic insights into the Bushen Huatan Huoxue Formula and its components in ameliorating obesity-associated polycystic ovary syndrome
- Inositols and other supplements in the management of PCOS
- Nanoformulated phytochemicals for PCOS: therapeutic potential, translational challenges, and future perspectives
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