Metformin and Other Insulin Sensitizers in Polycystic Ovary Syndrome
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Summary
There is no evidence that cardiovascular morbidity is decreased by long-term use of insulin sensitizers in PCOS women, and the QUICKI method is probably the best test to be used in PCos patients, preferably in a clinical trial context.
- Type
- review
- Published
- 2014-06-11
- Cited by
- 12
- References
- 49
- OpenAlex
- https://openalex.org/W2040104229
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8372061
Keywords
Polycystic ovary, Metformin, Insulin resistance, Medicine, Infertility
References
- PCOS: metabolic impact and long-term management.
- Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment.
- What may be the markers of the male equivalent of polycystic ovary syndrome?
- Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome.
- Current concepts of polycystic ovary syndrome.
- Commentary: polycystic ovary syndrome: a syndrome of ovarian hypersensitivity to insulin?
- Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy.
- Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.
- Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
- Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
- Options for combination therapy in type 2 diabetes: comparison of the ADA/EASD position statement and AACE/ACE algorithm.
- Managing anovulatory infertility and polycystic ovary syndrome
- Individualized Treatment of Type 2 Diabetes Mellitus Using Noninsulin Agents: Clinical Considerations for the Primary Care Physician
- The diagnosis of polycystic ovary syndrome in adolescents.
- Lifecycle of Polycystic Ovary Syndrome (PCOS): From In Utero to Menopause
- Metformin treatment of PCOS during adolescence and the reproductive period.
- Evaluating Reported Candidate Gene Associations with Polycystic Ovary Syndrome
- The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials.
- Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
- Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.
Cited by
- Can Animal Models of PCOS Help Point the Way Towards Early and Effective Therapeutic Intervention in Women With the Syndrome?
- Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.
- Expression and clinical significance of the HIF-1a/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome
- Adolescence and polycystic ovary syndrome: current concepts on diagnosis and treatment
- Síndrome de ovario poliquístico e infertilidad: Opciones de tratamiento
- Risk factors in adolescence for the development of polycystic ovary syndrome
- A model of ovulatory regulation examining the effects of insulin-mediated testosterone production on ovulatory function.
- Polycystic Ovary Syndrome: Explaining the Gynecological Aspects and Treatment Options to Patients
- What is new in the landscape of insulin-sensitizing agents for polycystic ovary syndrome treatment
- Comparative Evaluation of Aldose Reductase Inhibition in Polycystic Ovarian Syndrome–Induced Rats
- Effects of DMBG on Akt / HIF-1 a signaling in the ovaries of polycystic ovary syndrome rats
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