B cells and tertiary lymphoid structures promote immunotherapy response
Explore this paper's citation graph
Summary
B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
- Type
- article
- Published
- 2020-01-01
- Cited by
- 2,309
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2998795792
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:210221106
Keywords
Immune checkpoint, Immune system, Immunotherapy, Cancer research, Stromal cell
References
- tcR: an R package for T cell receptor repertoire advanced data analysis
- High endothelial venules (HEVs) in human melanoma lesions
- Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
- Genomic Classification of Cutaneous Melanoma
- The density and type of MECA‐79‐positive high endothelial venules correlate with lymphocytic infiltration and tumour regression in primary cutaneous melanoma
- Prognostic impact of B-cell density in cutaneous melanoma
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- Lymphatic vessels and tertiary lymphoid organs.
- Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor
- Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells.
- Tertiary lymphoid structures in cancer and beyond.
- Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer.
- Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
- Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers
- HTSeq—a Python framework to work with high-throughput sequencing data
- Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases.
- Controlling the false discovery rate in behavior genetics research.
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- Immunotype and Immunohistologic Characteristics of Tumor Infiltrating Immune Cells are Associated with Clinical Outcome in Metastatic Melanoma
- Cytoscape 2.8: new features for data integration and network visualization
Cited by
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
- Physics approaches to the spatial distribution of immune cells in tumors
- B cells are associated with survival and immunotherapy response in sarcoma
- Tertiary lymphoid structures improve immunotherapy and survival in melanoma
- B cells to the forefront of immunotherapy
- B cells, plasma cells and antibody repertoires in the tumour microenvironment
- Spatial transcriptomics of tumor microenvironment in formalin-fixed paraffin-embedded breast cancer
- Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
- B cells and TLSs facilitate a response to ICI
- Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
- Peripheral blood immune cell-based biomarkers in anti-PD-1/PD-L1 therapy
- Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses
- Redefining CD4 T cell residency: Helper T cells orchestrate protective humoral immunity in the lung
- Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune‐checkpoint inhibitors
- Molecular pathology of Lynch syndrome
- Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy
- Applying single‐cell technologies to clinical pathology: progress in nephropathology
- A single gene expressed in fibroblastic reticular cells predicts response to cancer immunotherapy
- Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma
- Chemotherapy Induces Cancer-Fighting B Cells.
Related papers
- Application and utility of mass cytometry in vaccine development
- Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
- Lanthanide‐Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry
- Analysis of Signaling Networks at the Single-Cell Level Using Mass Cytometry.
- Mass Cytometry for the Characterization of Individual Cell Types in Ovarian Solid Tumors
- Deep Profiling Human T Cell Heterogeneity by Mass Cytometry.
- Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders
- Exploration of the personalized immune checkpoint atlas of plasma cell dyscrasias patients using high-dimensional single-cell analysis