Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
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Summary
It is shown that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-treated patients.
- Type
- article
- Published
- 2020-02-12
- Cited by
- 30
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W3005685052
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:211081451
Keywords
Blockade, Melanoma, Stroma, Immune checkpoint, Cancer research
References
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- Primary resistance to PD-1 blockade mediated by JAK1/2 mutations
- Inference of immune cell composition on the expression profiles of mouse tissue
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- Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
Cited by
- Cell cycle regulation meets tumor immunosuppression
- Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis
- Activity-based urinary biomarkers of response and resistance to checkpoint blockade immunotherapy
- Identification of a Gene Signature for Renal Cell Carcinoma–Associated Fibroblasts Mediating Cancer Progression and Affecting Prognosis
- Melanoma models for the next generation of therapies
- Is the Immunogenicity of PD-1 Blocking Antibodies a Confounding Variable in Murine Studies?
- Cell cycle on the crossroad of tumorigenesis and cancer therapy
- FNA Cytological Diagnosis of Breast Metastasis From a Plantar Melanoma: Case Report
- Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors
- Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges.
- Identification of a Gene Signature of Cancer-Associated Fibroblasts to Predict Prognosis in Ovarian Cancer
- Identification of cuproptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in breast cancer
- From simplicity to complexity in current melanoma models
- Research Progress with Luteolin as an Anti-Tumor Agent
- Mouse models for immuno-oncology.
- The journey from melanocytes to melanoma
- Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis
- The role of coagulome in the tumor immune microenvironment
- Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells
- Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
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