Genomic Classification of Cutaneous Melanoma
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Summary
This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
- Type
- article
- Published
- 2015-06-18
- Cited by
- 2,792
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W1950829641
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2674263
Keywords
Biology, Melanoma, Mutant, Cancer research, Gene
References
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- Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics
- Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response.
- Time trends and latitudinal differences in melanoma thickness distribution in Australia, 1990–2006
- High frequency of BRAF mutations in nevi
- Melanoma thickness trends in the United States, 1988-2006.
- Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
- The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
- Distinct sets of genetic alterations in melanoma.
- Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial.
- Major response to imatinib mesylate in KIT-mutated melanoma.
- Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines
- IDH1 mutation identified in human melanoma
- Integrative Genomics Identifies Gene Signature Associated with Melanoma Ulceration
- Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
- Dose‐dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- TERT Promoter Mutations in Familial and Sporadic Melanoma
- UV Signature Mutations
Cited by
- The Sunbelt Melanoma Trial
- Treatment of melanoma brain metastases
- Low Levels of Genetic Heterogeneity in Matched Lymph Node Metastases from Patients with Melanoma.
- Transcriptional mechanisms of resistance to anti-PD-1 therapy
- Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel
- BAP1 mutations in high-grade meningioma: implications for patient care.
- Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy
- Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma.
- ALK inhibitor response in melanomas expressing EML4-ALK fusions and alternate ALK isoforms
- Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
- Primary and metastatic melanoma with NTRK-Fusions
- MEK inhibition may increase survival of NRAS-mutated melanoma patients treated with checkpoint blockade: Results of a retrospective multicentre analysis of 364 patients.
- Ultraviolet radiation-mediated development of cutaneous melanoma: An update.
- CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma
- Sun Exposure and Melanoma, Certainties and Weaknesses of the Present Knowledge
- Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor‐infiltrating lymphocytes) in superficial spreading and nodular melanoma
- Recurrent noncoding mutations in skin cancers: UV damage susceptibility or repair inhibition as primary driver?
- Perturbation biology links temporal protein changes to drug responses in a melanoma cell line
- Effects of Molecular Heterogeneity on Survival of Patients With BRAFV600-Mutated Melanoma Treated With Vemurafenib With or Without Cobimetinib in the coBRIM Study.
- Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma.
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