Attenuated Tregs increase susceptibility to type 1 diabetes in prenatal nicotine exposed female offspring mice.
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Summary
In conclusion, PNE resulted in metabolic changes of offspring that were consistent with T1D characteristics, which could be the consequence of Tregs recession from early life to adolescence.
- Type
- article
- Published
- 2019-08-20
- Cited by
- 4
- References
- 80
- OpenAlex
- https://openalex.org/W2969932063
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:201631272
Keywords
Offspring, Nicotine, Endocrinology, Internal medicine, Medicine
References
- Targeting of Pancreatic Glia in Type 1 Diabetes
- Early life exposure to environmental tobacco smoke alters immune response to asbestos via a shift in inflammatory phenotype resulting in increased disease development
- Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers.
- Early-Life Exposure to Substance Abuse and Risk of Type 2 Diabetes in Adulthood
- Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients
- Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
- Type 1 Diabetes-associated IL2RAvariationlowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T-cell function
- Consequences of smoking for body weight, body fat distribution, and insulin resistance.
- Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine.
- Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
- Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis
- Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype
- The maternal and fetal physiologic effects of nicotine.
- Thymic regulatory T cells.
- Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation
- Maternal nicotine exposure increases oxidative stress in the offspring.
- Maternal smoking during pregnancy and the risk of childhood type 1 diabetes in Western Australia
- A comprehensive guide to antibody and T-cell responses in type 1 diabetes.
- A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis
- The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes
Cited by
- Augmented autophagy suppresses thymocytes development via Bcl10/p-p65 pathway in prenatal nicotine exposed fetal mice.
- Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review
- Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes
- Maternal smoking during pregnancy and risk of childhood-onset type 1 diabetes in offspring: A systematic review and meta-analysis
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