NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury
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Summary
It is demonstrated that NEK7, as a modulator, regulates NLRP3 inflammasomes and downstream neuroinflammation in response to K+ efflux, through NEK 7–NLRP3 assembly, pro-caspase-1 recruitment, caspases-1 activation, and pyroptosis in nerve injuries, post-TBI.
- Type
- article
- Published
- 2019-08-29
- Cited by
- 64
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2966760137
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:201211625
Keywords
Inflammasome, Pyrin domain, Neuroinflammation, Traumatic brain injury, Pyroptosis
References
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- Gasdermin D: the long-awaited executioner of pyroptosis
- What has inflammation to do with traumatic brain injury?
- A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation*
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- Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux
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- Recombinant human interleukin-1 receptor antagonist promotes M1 microglia biased cytokines and chemokines following human traumatic brain injury
- NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases.
- Roles of Caspases in Necrotic Cell Death
Cited by
- Current trends in biomarker discovery and analysis tools for traumatic brain injury
- MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury
- Clinical Applications of Extracellular Vesicles in the Diagnosis and Treatment of Traumatic Brain Injury
- Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice
- Regulated Cell Death in Pulpitis.
- NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma
- The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury
- Low Molecular Weight Dextran Sulfate (ILB®) Administration Restores Brain Energy Metabolism Following Severe Traumatic Brain Injury in the Rat
- Therapeutic potential of sulfur-containing natural products in inflammatory diseases.
- NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.
- Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway
- The neuroprotection of hyperbaric oxygen therapy against traumatic brain injury via NF-κB/MAPKs-CXCL1 signaling pathways
- c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
- Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain
- On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response
- NANO DOT BLOT: AN ALTERNATIVE TECHNIQUE FOR PROTEIN IDENTIFICATION AND QUANTIFICATION IN A HIGH THROUGHPUT FORMAT.
- Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis
- Pyroptosis: A promising therapeutic target for noninfectious diseases
- The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer’s Disease
- Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury
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