Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells

Explore this paper's citation graph

Summary

It is shown that the human monocytic cell line THP1 activates the inflammasome in response to cytosolic LPS in a TLR4‐independent fashion, providing evidence for the presence of a non‐canonical inflammaome in humans and its dependence on caspase‐4.

Type
article
Published
2015-10-01
Cited by
302
References
20
Access
Open access

Keywords

Inflammasome, Myeloid cells, Biology, Non canonical, Cell biology

References

Cited by

Related papers