Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells
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Summary
It is shown that the human monocytic cell line THP1 activates the inflammasome in response to cytosolic LPS in a TLR4‐independent fashion, providing evidence for the presence of a non‐canonical inflammaome in humans and its dependence on caspase‐4.
- Type
- article
- Published
- 2015-10-01
- Cited by
- 302
- References
- 20
- Access
- Open access
- OpenAlex
- https://openalex.org/W2164406361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5877980
Keywords
Inflammasome, Myeloid cells, Biology, Non canonical, Cell biology
References
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- A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling
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Cited by
- A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells.
- Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways
- NLRP3 inflammasome and its inhibitors: a review
- Converging roles of caspases in inflammasome activation, cell death and innate immunity
- Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome
- Inflammasomes as polyvalent cell death platforms
- Interleukin-1 signalling in disease
- Human Monocytes Engage an Alternative Inflammasome Pathway.
- Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12
- A molecular analysis of the interactions of Escherichia coli and macrophages
- A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function
- Inflammasomes: mechanism of assembly, regulation and signalling
- The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
- Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation
- Interferons and inflammasomes: Cooperation and counterregulation in disease.
- Salmonella and the Inflammasome: Battle for Intracellular Dominance.
- General Strategies in Inflammasome Biology.
- The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits.
- Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release.
- Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4
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