Down-regulation of CCL17 in cancer-associated fibroblasts inhibits cell migration and invasion of breast cancer through ERK1/2 pathway
Explore this paper's citation graph
Summary
CCL17 may function as a novel biomarker as well as potential therapeutic target against BC and CAF-secreted CCL17 promotes BC cell migration and invasion through the DUSP6-dependent ERK1/2 pathway.
- Type
- article
- Published
- 2019-08-07
- Cited by
- 13
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W4402100072
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:201169530
Keywords
Cancer-Associated Fibroblasts, Cancer, Breast cancer, Cancer research, Cell migration
References
- Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling.
- Increased CCL17 serum levels are associated with improved survival in advanced melanoma
- Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment.
- The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer
- Tumor suppressor dual‐specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial‐mesenchymal transition (EMT)‐associated phenotype
- DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5.
- Biological Characteristics and Genetic Heterogeneity between Carcinoma-Associated Fibroblasts and Their Paired Normal Fibroblasts in Human Breast Cancer
- LncRNA expression signatures of twist-induced epithelial-to-mesenchymal transition in MCF10A cells.
- TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer
- Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells.
- Selective deregulation in chemokine signaling pathways of CD4+CD25hiCD127lo/− regulatory T cells in human allergic asthma
- CXCL12/CXCR4 activation by cancer‐associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer
- DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.
- The nuclear factor NF-kappaB pathway in inflammation.
- CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway.
- Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and T regulatory cells
- Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling
- Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation
- AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression
- Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
Cited by
- Phosphorylation of Yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restriction†
- TRIM65 promotes invasion of endometrial stromal cells by activating ERK1/2/C-myc signaling via ubiquitination of DUSP6.
- The Detection of Plasma Soluble Podoplanin of Patients with Breast Cancer and Its Clinical Signification
- Apolipoprotein E2 Promotes the Migration and Invasion of Pancreatic Cancer Cells via Activation of the ERK1/2 Signaling Pathway
- Senescent thyroid tumor cells promote their migration by inducing the polarization of M2-like macrophages
- Identification of a Six-Gene Signature for Predicting the Overall Survival of Cervical Cancer Patients
- Chemokine signaling in cancer-stroma communications
- Chemokine Homeostasis in Healthy Volunteers and during Pancreatic and Colorectal Tumor Growth in Murine Models
- ERK/STAT3 activation through CCL17/CCR4 axis-mediated type 2 cytokine-involved signaling pathways in Th2 cells regulates cutaneous drug reactions.
- Recent advances targeting chemokines for breast cancer.
- OTT_A_276553 809..822
- CMAR_A_281785 13207..13214
Related papers
- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.
- Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells.
- Cancer-Associated Fibroblasts Differentiated by Exosomes Isolated from Cancer Cells Promote Cancer Cell Invasion
- Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion
- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells.
- Abstract 5087: EMT in cancer cells promotes the extracellular matrix remodeling by cancer-associated fibroblasts
- Glycopolymer Engineering of the Cell Surface Changes the Single Cell Migratory Direction and Inhibits the Collective Migration of Cancer Cells.
- Coordination of cell migration mediated by site-dependent cell–cell contact
- Potential of Gold Nanoparticles in Current Radiotherapy Using a Co-Culture Model of Cancer Cells and Cancer Associated Fibroblasts Cells