AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression
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Summary
Findings revealed that AJUBA serves as oncogenic gene in ESCC and may serve as a new target for ESCC therapy and upregulates the levels of MMP10 and MMP13 by activating ERK1/2.
- Type
- article
- Published
- 2016-05-09
- Cited by
- 42
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2345882527
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:937825
Keywords
Downregulation and upregulation, LIM domain, Cell biology, Cancer research, Cell
References
- Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma.
- A novel mechanism for activation of Aurora-A kinase by Ajuba.
- Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma
- Regulation of matrix metalloproteinase expression in tumor invasion
- Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation
- Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production
- Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry
- Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins
- Comprehensive genomic characterization of head and neck squamous cell carcinomas
- Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China
- LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade
- Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.
- Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.
- LIM protein JUB promotes epithelial–mesenchymal transition in colorectal cancer
- The Hippo pathway and human cancer
- Two newly identified sites in the N-terminal regulatory domain of Aurora-A are essential for auto-inhibition
- Genetic landscape of esophageal squamous cell carcinoma
- Epidemiology of esophageal cancer.
- Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
- The LIM Protein Ajuba Is Recruited to Cadherin-dependent Cell Junctions through an Association with α-Catenin*
Cited by
- Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells
- Androgen receptor‐regulated miRNA‐193a‐3p targets AJUBA to promote prostate cancer cell migration
- The global expression profiling in esophageal squamous cell carcinoma.
- High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation
- LIM Protein Ajuba Directly Interacts with Replication Protein A to Prevent ATR DNA Damage Response
- Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance
- AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer.
- Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p
- Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
- Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation
- Ajuba overexpression regulates mitochondrial potential and glucose uptake through YAP/Bcl-xL/GLUT1 in human gastric cancer.
- Dual-strand tumor suppressor miR-193b-3p and -5p inhibit malignant phenotypes of lung cancer by suppressing their common targets
- Down-regulation of CCL17 in cancer-associated fibroblasts inhibits cell migration and invasion of breast cancer through ERK1/2 pathway
- Identifying and targeting LIM-domain loss in clear cell renal cell carcinoma
- p38‐regulated FOXC1 stability is required for colorectal cancer metastasis
- Ajuba: an emerging signal transducer in oncogenesis.
- Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma.
- The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer
- Polyphenol-Enriched Extracts from Trapa acornis Husks Inhibit Her2-Positive SK-BR-3 Breast Cancer Cell Proliferation and In Vivo Tumor Angiogenesis
- AJUBA: A regulator of epidermal homeostasis and cancer
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