The Oncogene IARS2 Promotes Non-small Cell Lung Cancer Tumorigenesis by Activating the AKT/MTOR Pathway
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Summary
The results help clarify the complex roles of IARS2 in tumorigenesis and suggest that it may be a novel regulator of lung cancer development.
- Type
- article
- Published
- 2019-05-14
- Cited by
- 34
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2945826391
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:153310787
Keywords
PI3K/AKT/mTOR pathway, Carcinogenesis, Cancer research, Protein kinase B, Oncogene
References
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- The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer.
- Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis
Cited by
- Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors
- FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway
- SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
- HAX1 enhances the survival and metastasis of non‐small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway
- Novel functions of cytoplasmic aminoacyl-tRNA synthetases shaping the hallmarks of cancer.
- Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
- tRNA Metabolism and Lung Cancer: Beyond Translation
- Identification of a Nuclear Mitochondrial-Related Multi-Genes Signature to Predict the Prognosis of Bladder Cancer
- A Novel Mitochondrial-Related Nuclear Gene Signature Predicts Overall Survival of Lung Adenocarcinoma Patients
- Understanding the genomic architecture of clinical mastitis in Bos indicus
- Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk‐3β signal pathway
- Regulation of apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review)
- Wnt signaling and plasticity of lung cancer cells
- Lentivirus-induced knockdown of IARS2 expression inhibits the proliferation and promotes the apoptosis of human osteosarcoma cells
- Aminoacyl‐tRNA synthetase – a molecular multitasker
- DARS2 promotes the occurrence of lung adenocarcinoma via the ERK/c‐Myc signaling pathway
- FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway
- From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer.
- Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study
- Recent advancement in pyrrolidine moiety for the management of cancer: A review
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