Hypoxia Signature of Splice Forms of Tryptophanyl-tRNA Synthetase Marks Pancreatic Cancer Cells With Distinct Metastatic Abilities
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Summary
Tryptophanyl-tRNA synthetase down-regulation by hypoxia may be a factor responsible for low TrpRS in tumors with high metastatic ability and as a new target for metastasis treatment.
- Type
- article
- Published
- 2011-10-01
- Cited by
- 23
- References
- 35
- OpenAlex
- https://openalex.org/W1973735953
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33998957
Keywords
Pancreatic cancer, Cancer research, Biology, Metastasis, Prostate cancer
References
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- Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity.
- Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer
- Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array
- Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
- Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease.
- Tryptophanyl-tRNA synthetase in cell lines resistant to tryptophan analogs.
- Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis.
- Termination of Quiescence in Crustacea
- Differential protein synthesis and expression levels in normal and neoplastic human prostate cells and their regulation by type I and II interferons
- Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models
- Cytotoxicity of Simvastatin to Pancreatic Adenocarcinoma Cells Containing Mutant ras Gene
- An exposed cysteine residue of human angiostatic mini tryptophanyl-tRNA synthetase.
- Assignment of the human tryptophanyl-tRNA synthetase gene (WARS) to chromosome 14q32.2 --> q32.32.
- A mammalian tryptophanyl-tRNA synthetase is associated with protein kinase activity.
- Limited proteolysis of tryptophanyl-tRNA synthetase from beef pancreas.
Cited by
- Association of aminoacyl-tRNA synthetases with cancer.
- Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness
- Current and future intratumoral targeted treatment for pancreatic cancer.
- Essential Non-Translational Functions of tRNA Synthetases
- Chaperon-like Activation of Serum-Inducible Tryptophanyl-tRNA Synthetase Phosphorylation through Refolding as a Tool for Analysis of Clinical Samples.
- Towards an Integrative Understanding of tRNA Aminoacylation–Diet–Host–Gut Microbiome Interactions in Neurodegeneration
- Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited
- Diet-Related Metabolic Perturbations of Gut Microbial Shikimate Pathway-Tryptamine-tRNA Aminoacylation-Protein Synthesis in Human Health and Disease
- The Oncogene IARS2 Promotes Non-small Cell Lung Cancer Tumorigenesis by Activating the AKT/MTOR Pathway
- Discovery of Gut Bacteria Specific to Alzheimer’s Associated Diseases is a Clue to Understanding Disease Etiology: Meta-Analysis of Population-Based Data on Human Gut Metagenomics and Metabolomics
- Tryptophanyl-tRNA synthetase (WARS) expression in uveal melanoma – possible contributor during uveal melanoma progression
- Prognostic Implications of Metabolism Related Gene Signature in Cutaneous Melanoma
- Aminoacyl-tRNA Synthetases and amino acid signaling.
- Identification of prognostic genes in uveal melanoma microenvironment
- Identifying Dendritic Cell–Related Genes Through a Co-Expression Network to Construct a 12-Gene Risk-Scoring Model for Predicting Hepatocellular Carcinoma Prognosis
- tRNA modifications and their potential roles in pancreatic cancer.
- New Candidates for Biomarkers and Drug Targets of Ischemic Stroke—A First Dynamic LC-MS Human Serum Proteomic Study
- The pathophyiological role of aminoacyl-tRNA synthetases in digestive system diseases
- Clinical Significance of Tryptophanyl-tRNA Synthetase 1 Gene Expression in Patients With Locally Advanced Gastric Cancer
- Hypoxia and immunometabolism in the tumor microenvironment: insights into mechanisms and therapeutic potential.
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