The chemical biology of apoptosis: Revisited after 17 years.
Explore this paper's citation graph
Summary
The progress and current status of small molecule Bcl-2 inhibitor development is examined, demonstrating the B cl-2 family as a valid target for cancer therapy and providing successful examples for the discovery of inhibitors that target protein-protein interactions.
- Type
- review
- Published
- 2019-09-01
- Cited by
- 31
- References
- 115
- Access
- Open access
- OpenAlex
- https://openalex.org/W2944790786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:165053818
Keywords
Apoptosis, Chemical biology, Bcl-2 family, Small molecule, Downregulation and upregulation
References
- The BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics
- Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
- Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
- Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.
- Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside.
- Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner
- Cell death and the mitochondria: therapeutic targeting of the BCL‐2 family‐driven pathway
- Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas
- Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment
- An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins
- BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins
- An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies
- Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1.
- Bcl-2 family proteins are essential for platelet survival
- The BCL-2 protein family: opposing activities that mediate cell death
- A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-dependent Leukemia Cell Survival
- Targeting BCL2 for the treatment of lymphoid malignancies.
- A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor
- Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
- Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
Cited by
- The response of normal tissues to synchrotron microbeam radiotherapy
- Oxymatrine Exerts Organ- and Tissue-Protective Effects by Regulating Inflammation, Oxidative Stress, Apoptosis, and Fibrosis: From Bench to Bedside.
- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
- Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target.
- Effects of Hydroalcoholic Leaf Extract of Avicennia marina on Apoptotic, Inflammatory, Oxidative Stress, and Lipid Peroxidation Indices and Liver Histology of Type 1 Diabetic Rats
- Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells
- A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
- The functional role of long non-coding RNAs and their underlying mechanisms in drug resistance of non-small cell lung cancer.
- Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors.
- Theasaponin E1 Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis
- New bioactive 5-arylcarboximidamidopyrazolo[3,4-c]pyridines: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.
- Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
- Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin
- Designing of various biosensor devices for determination of apoptosis: A comprehensive review.
- Boldine Activates Intrinsic Apoptotic Pathway in DU-145 Androgen-Independent Prostate Cancer Cell Line
- Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis
- Cell-penetrating peptide-mediated delivery of therapeutic peptides/proteins to manage the diseases involving oxidative stress, inflammatory response and apoptosis.
- The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
- Antiproliferative Evaluation of Novel 4-Imidazolidinone Derivatives as Anticancer Agent Which Triggers ROS-Dependent Apoptosis in Colorectal Cancer Cell
- Water-soluble Yb3+, Er3+ codoped NaYF4 nanoparticles induced SGC-7901 cell apoptosis through mitochondrial dysfunction and ROS-mediated ER stress
Related papers
- Finding Small Molecule Ligands for Protein-Protein Interactions and Other “Undruggable” Targets
- Pharmacological manipulation of Bcl-2 family members to control cell death.
- Nature Inspired Small Molecules for Chemical Biology
- Chemistry and biology for the small molecules targeting characteristics of cancer cells
- Targeting the Undruggable Proteome: The Small Molecules of My Dreams
- Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules
- Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets.
- Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists.
- Seeing small molecules in action with bioorthogonal chemistry.