Cell death and the mitochondria: therapeutic targeting of the BCL‐2 family‐driven pathway
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Summary
Modulating the activity of the BCL‐2 family of proteins with small molecules or peptides is an attractive but challenging therapeutic goal and evidence that this strategy is likely to have a positive effect on the treatment of still poorly addressed medical conditions is provided.
- Type
- article
- Published
- 2014-04-01
- Cited by
- 118
- References
- 145
- Access
- Open access
- OpenAlex
- https://openalex.org/W1707073754
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8428320
Keywords
Mitochondrion, Cell biology, Programmed cell death, Biology, Bcl-2 family
References
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- Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer.
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- Inhibition of Bax-Induced Cytochrome c Release from Neural Cell and Brain Mitochondria by Dibucaine and Propranolol
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- X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
- Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces*
- Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
- The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.
- BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins
- Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
- The hallmarks of cancer
- Bcl-2 family proteins are essential for platelet survival
Cited by
- Molecular mechanisms of apoptosis and roles in cancer development and treatment.
- Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells.
- New dimension in therapeutic targeting of BCL-2 family proteins
- Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity
- The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines
- Apoptosis as a Therapeutic Target in Chronic Lymphocytic Leukemia
- The mechanism of acacetin-induced apoptosis on oral squamous cell carcinoma.
- Compound A398, a Novel Podophyllotoxin Analogue: Cytotoxicity and Induction of Apoptosis in Human Leukemia Cells
- BCL-2 is dispensable for thrombopoiesis and platelet survival
- Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer
- Strategies targeting apoptosis proteins to improve therapy of chronic lymphocytic leukemia.
- A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo
- Peptides derived from the transmembrane domain of Bcl-2 proteins as potential mitochondrial priming tools.
- Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-α-Treated Rat Aortic Smooth Muscle Cells
- Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis.
- Effects of bergamot essential oil and its extractive fractions on SH‐SY5Y human neuroblastoma cell growth
- Optogenetic Apoptosis: Light-Triggered Cell Death
- First MCL-1-selective BH3 mimetics as potential therapeutics for targeted treatment of cancer
- Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer
- MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells
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