Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Explore this paper's citation graph
Summary
The development of both positive and negative small-molecule modulators of apoptosis is now enabling researchers to translate the discoveries that have been made in the laboratory into clinical practice to positively impact human health.
- Type
- article
- Published
- 2019-01-17
- Cited by
- 1,844
- References
- 235
- OpenAlex
- https://openalex.org/W30655609
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:58014945
Keywords
Computer science
References
- Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
- The proliferation rate paradox in antimitotic chemotherapy
- Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
- Mitochondrial DNA in innate immune responses and inflammatory pathology
- Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
- HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
- The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
- Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease
- BAX Contributes to Apoptotic-Like Death Following Neonatal Hypoxia-Ischemia: Evidence for Distinct Apoptosis Pathways
- A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
- Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons
- Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers
- Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection.
- tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c.
- Apoptosis and Oxidative Stress in Neurodegenerative Diseases
- Silencing Egr1 Attenuates Radiation-induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth
- The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim
- Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?
- Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
- A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
Cited by
- Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living.
- Clonal plasma cells in AL amyloidosis are dependent on pro-survival BCL-2 family proteins and sensitive to BH3 mimetics
- Rising horizon in circumventing multidrug resistance in chemotherapy with nanotechnology.
- The molecular machinery of regulated cell death
- A reference map of the human protein interactome
- Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5
- Effects of Intestinal Microbial–Elaborated Butyrate on Oncogenic Signaling Pathways
- The chemical biology of apoptosis: Revisited after 17 years.
- Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
- Aedes aegypti saliva impairs M1-associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages
- Activation of NF-κB pathways mediating the inflammation and pulmonary diseases associated with atmospheric methylamine exposure.
- Autophagy-Independent Functions of the Autophagy Machinery
- The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis.
- Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol-induced neurotoxicity in the hippocampus of neonatal rats
- Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen
- Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.
- Preparation, characteristics and feeble induced-apoptosis performance of non-dialysis requiring selenium nanoparticles@chitosan
- Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis
- Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate.
- Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer
Related papers
No related papers recorded.