Single-cell transcriptomic analysis of Alzheimer’s disease
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Summary
Single-cell transcriptomics from 48 individuals with varying degrees of Alzheimer's disease pathology demonstrates that gene-expression changes in Alzheimer’s disease are both cell-type specific and shared, and that transcriptional responses show sexual dimorphism.
- Type
- article
- Published
- 2019-04-24
- Cited by
- 2,223
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2942678593
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:143421603
Keywords
Transcriptome, Disease, Biology, Cell type, Alzheimer's disease
References
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- Early endosome localization and activity of RasGEF1b, a toll-like receptor-inducible Ras guanine-nucleotide exchange factor
- Protective and therapeutic role for αB-crystallin in autoimmune demyelination
- Clusterin enhances proliferation of primary astrocytes through extracellular signal-regulated kinase activation
- Neuropathological stageing of Alzheimer-related changes
- In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
- Spatial registration and normalization of images
- Natural history of mild cognitive impairment in older persons
- Adapting Proteostasis for Disease Intervention
- Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease.
Cited by
- Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans
- Molecular Signatures of the Aging Brain: Finding the Links Between Genes and Phenotypes
- Connecting gene regulatory relationships to neurobiological mechanisms of brain disorders
- An 80,000-Piece Puzzle of Alzheimer's Disease.
- Restoring synaptic function through multimodal therapeutics.
- A2AR‐induced transcriptional deregulation in astrocytes: An in vitro study
- Genome-wide, integrative analysis implicates circular RNA dysregulation in autism and the corresponding circular RNA-microRNA-mRNA regulatory axes
- The interplay between microglial states and major risk factors in Alzheimer's disease through the eyes of single-cell RNA-sequencing: beyond black and white.
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
- Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease
- Neuroinflammation als Motor der Alzheimer-Erkrankung
- Single-Cell Quantification of mRNA Expression in The Human Brain
- Cell Population Effects in a Mouse Tauopathy Model Identified by Single Cell Sequencing
- The AD Exposome
- Role of physical nucleation theory in understanding conformational conversion between pathogenic and nonpathogenic aggregates of low-complexity amyloid peptides
- Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleus
- Iron Ion-Releasing Polypeptide Thermogel for Neuronal Differentiation of Mesenchymal Stem Cells.
- Natural representation of composite data with replicated autoencoders
- Single-cell RNA-Sequencing in Neuroscience
- Single cell transcriptome profiling of the human alcohol-dependent brain
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