Protective and therapeutic role for αB-crystallin in autoimmune demyelination
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Summary
It is demonstrated that CRYAB is a potent negative regulator acting as a brake on several inflammatory pathways in both the immune system and central nervous system (CNS), and the immune response against a negative regulator of inflammation,CRYAB, in multiple sclerosis, would exacerbate inflammation and demyelination.
- Type
- article
- Published
- 2007-07-26
- Cited by
- 488
- References
- 40
- OpenAlex
- https://openalex.org/W2047579358
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4392693
Keywords
Experimental autoimmune encephalomyelitis, Multiple sclerosis, Neuroprotection, Immune system, Inflammation
References
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- The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis
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- Human bcl-2 Gene Attenuates the Ability of Rabbit Lens Epithelial Cells against H2O2-induced Apoptosis through Down-regulation of the αB-crystallin Gene*
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- Differential Protective Activity of αA- and αB-crystallin in Lens Epithelial Cells*
- Identification of tryptophan oxidation products in bovine α‐crystallin
Cited by
- Dealing with Danger in the CNS: The Response of the Immune System to Injury
- Disease biomarkers in multiple sclerosis: potential for use in therapeutic decision making.
- The good and the bad of neuroinflammation in multiple sclerosis.
- Alpha B-crystallin correlates with poor survival in colorectal cancer.
- Epidémiologie de la sclérose en plaques en France
- Role of crystallins in diabetic complications.
- Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.
- Endothelial activation and inflammation in the tumor microenvironment
- Alpha Crystallins in the Retinal Pigment Epithelium and Implications for the Pathogenesis and Treatment of Age-Related Macular Degeneration
- Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment
- Crystallins and neuroinflammation: the glial side of the story
- Structure and function of α-crystallins: Traversing from in vitro to in vivo.
- Adipose tissue secretion and inflammation - Characterization of novel adipokines and the impact of hypoxia on adipocyte function
- Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis
- A genetic study of the FMR1 gene in a Sardinian multiple sclerosis population
- A study of biomarker analysis in association with type 1 diabetes and their shared features in rheumatoid arthritis
- Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin‐2
- Phosphorylation of Ser45 and Ser59 of αB‐crystallin and p38/extracellular regulated kinase activity determine αB‐crystallin‐mediated protection of rat brain astrocytes from C2‐ceramide‐ and staurosporine‐induced cell death
- New and emerging immune‐targeted drugs for the treatment of multiple sclerosis
- Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis.
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