Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma
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Summary
The following article will discuss the current understanding of autophagy signaling in pHGG and the potential modulation of this network as a therapeutic target.
- Type
- review
- Published
- 2019-05-13
- Cited by
- 15
- References
- 162
- Access
- Open access
- OpenAlex
- https://openalex.org/W2942036840
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:128362991
Keywords
Autophagy, Crosstalk, Glioma, Downregulation and upregulation, Cancer research
References
- CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.
- Autophagy and the Cell Cycle: A Complex Landscape
- Autophagy and its role in gastric cancer.
- Drugging PI3K in cancer: refining targets and therapeutic strategies
- DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
- Autophagy at the crossroads of catabolism and anabolism
- Divergent roles of BECN1 in LC3 lipidation and autophagosomal function
- Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment
- Will Kinase Inhibitors Make it as Glioblastoma Drugs?
- Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors
- AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells
- MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
- The mTOR Signalling Pathway in Human Cancer
- Autophagy and lysosomal related protein expression patterns in human glioblastoma
- Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
- Space Flight Effects on Antioxidant Molecules in Dry Tardigrades: The TARDIKISS Experiment
- Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
- DNA damage and autophagy
- Autophagy-driven cell fate decision maker: Activated microglia induce specific death of glioma cells by a blockade of basal autophagic flux and secondary apoptosis/necrosis
- Mammalian autophagy: core molecular machinery and signaling regulation
Cited by
- Glioblastoma: targeting the autophagy in tumorigenesis.
- Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons
- A human co‐culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics
- Development and validation of a nomogram with an autophagy-related gene signature for predicting survival in patients with glioblastoma
- Circular RNA ITCH: A novel tumor suppressor in multiple cancers.
- Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma
- Identification of a Metabolism-Related Risk Signature Associated With Clinical Prognosis in Glioblastoma Using Integrated Bioinformatic Analysis
- Recent Advances in Understanding the Role of Autophagy in Paediatric Brain Tumours
- ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression
- Doramectin inhibits glioblastoma cell survival via regulation of autophagy in vitro and in vivo
- Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation.
- DNA damage-regulated autophagy modulator 1 prevents glioblastoma cells proliferation by regulating lysosomal function and autophagic flux stability.
- DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay
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