IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger
Explore this paper's citation graph
Summary
The downstream phenotype of reduced antibody production in Irf5 −/− mice was conserved between T cell‐dependent and TLR9‐dependent immunisation, and the mechanisms leading to this phenotype were antigen‐ and cell type‐specific.
- Type
- article
- Published
- 2024-11-21
- Cited by
- 5
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W4404621730
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:274178464
Keywords
IRF5, Immunology, Immune system, Autoantibody, Antigen
References
- IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE.
- Type I interferon in systemic lupus erythematosus.
- Interplay of Cytokines and Chemokines in the Pathogenesis of Systemic Lupus Erythematosus
- Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease.
- Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics
- Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
- Protection of Irf5-deficient mice from pristane-induced lupus involves altered cytokine production and class switching
- IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis
- IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
- TLR7 and TLR9 in SLE: when sensing self goes wrong
- Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.
- IRF5 is required for late-phase TNF secretion by human dendritic cells.
- Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus
- A volcanic explosion of autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients.
- Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
- Emerging roles of TLR7 and TLR9 in murine SLE.
- The evolution of human anti-double-stranded DNA autoantibodies.
- Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
- A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
- Bcl6 Mediates the Development of T Follicular Helper Cells
Cited by
- Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients
- The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles
- B细胞内源性拟素化可调控小鼠免疫反应
- The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice
Related papers
- Detection of Autoantibodies to Tumour‐Associated Antigens in Sera of Patients with Systemic Autoimmunity Using a Novel Protein Microblot Array
- BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.
- B-cell tolerance breakdown in Sjögren's syndrome: focus on BAFF.
- Requirement for BAFF and APRIL during B Cell Development in GALT
- B Cell Activating Factor (BAFF) and T Cells Cooperate to Breach B Cell Tolerance in Lupus-Prone New Zealand Black (NZB) Mice
- BLyS Neutralization Ablates Primary But Not Memory B Cell Pools
- BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms
- The effect of BLyS neutralization on primary B cell compartments and responses (B31)