Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

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Summary

It is found that BCAP has a functional N-terminal TIR homology domain and links TLR signaling to activation of PI3K, and negatively regulates proinflammatory cytokine secretion upon TLR stimulation.

Type
article
Published
2011-12-20
Cited by
194
References
47
Access
Open access

Keywords

TRIF, Cell biology, Signal transduction, PI3K/AKT/mTOR pathway, Protein kinase B

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