Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
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Summary
It is found that BCAP has a functional N-terminal TIR homology domain and links TLR signaling to activation of PI3K, and negatively regulates proinflammatory cytokine secretion upon TLR stimulation.
- Type
- article
- Published
- 2011-12-20
- Cited by
- 194
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012671933
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11405206
Keywords
TRIF, Cell biology, Signal transduction, PI3K/AKT/mTOR pathway, Protein kinase B
References
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- TLR signaling augments macrophage bactericidal activity through mitochondrial ROS
- PI3K-mediated negative feedback regulation of IL-12 production in DCs
- TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
- Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement.
- Drosophila MyD88 is an adapter in the Toll signaling pathway
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- Pattern recognition receptors and inflammation.
- SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling
- The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
- Contribution of BCAP to maintenance of mature B cells through c-Rel
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- CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
- Beta2 Integrins Inhibit TLR Responses by Reducing NF-kappaB Pathway Activation
- The effects of HIV on the regulation of IL-12 family cytokines, IL-12, IL-23, and IL-27 production in human monocyte-derived macrophages
- Modulation fonctionnelle des cellules dendritiques par les « Neutrophil Extracellular Traps »
- The Role of p110δ in the Development and Activation of B Lymphocytes.
- TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPases
- The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages
- Molecular Mechanism Involved in HIV-Tat Mediated inhibition of LPS-Induced IL-23 and IL-27 Production in Human Macrophages
- Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia
- Control of macrophage metabolism and activation by mTOR and Akt signaling
- Investigation of the role of toll-like and interleukin-6 receptors in peritoneal inflammatory responses to infection
- IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses
- Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme
- Novel drugs targeting Toll-like receptors for antiviral therapy
- Adaptors in toll-like receptor signaling and their potential as therapeutic targets.
- Negative regulatory approaches to the attenuation of Toll-like receptor signaling
- Signaling mechanisms regulating B-lymphocyte activation and tolerance
- The history of Toll-like receptors — redefining innate immunity
- Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide
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