Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Explore this paper's citation graph
Summary
A biologist-oriented portal that provides a gene list annotation, enrichment and interactome resource and enables integrated analysis of multi-OMICs datasets, which is an effective and efficient tool for experimental biologists to comprehensively analyze and interpret OMICs-based studies in the big data era.
- Type
- article
- Published
- 2019-04-03
- Cited by
- 12,484
- References
- 70
- Access
- Open access
- OpenAlex
- https://openalex.org/W2928665623
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:92997124
Keywords
Computer science, Interactome, Annotation, Inference, Pipeline (software)
References
- Saccharomyces Genome Database: the genomics resource of budding yeast
- Pathway and Network Analysis of Cancer Genomes
- Meta-analysis methods for genome-wide association studies and beyond
- GREAT improves functional interpretation of cis-regulatory regions
- The Reactome pathway Knowledgebase
- Babelomics 5.0: functional interpretation for new generations of genomic data
- Single-cell and multivariate approaches in genetic perturbation screens
- IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus
- A Coefficient of Agreement for Nominal Scales
- g:Profiler—a web server for functional interpretation of gene lists (2011 update)
- Human Host Factors Required for Influenza Virus Replication
- Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
- Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency
- GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis
- Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
- A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma
- Gene Ontology: tool for the unification of biology
- GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists
- More powerful procedures for multiple significance testing.
- ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
Cited by
- Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
- Network Pharmacology-Based Dissection of the Mechanism of Drynariae Rhizoma for Low Back Pain
- Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling
- Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages
- B cell subsets-related biomarkers and molecular pathways for systemic lupus erythematosus by transcriptomics analyses.
- Meta-Analysis of Hypoxic Transcriptomes from Public Databases
- Xanthones from Gentianella acuta (Michx.) Hulten Ameliorate Colorectal Carcinoma via the PI3K/Akt/mTOR Signaling Pathway
- Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei
- Dedifferentiation and neuronal repression define familial Alzheimer’s disease
- HMGB1 as a rheostat of chromatin topology and RNA homeostasis on the path to senescence
- Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers
- Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
- Integration of a Computational Pipeline for Dynamic Inference of Gene Regulatory Networks in Single Cells
- Single-cell transcriptomic analysis of Alzheimer’s disease
- Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription control
- Analysis of Genes Involved in Ulcerative Colitis Activity and Tumorigenesis Through Systematic Mining of Gene Co-expression Networks
- eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health
- Pathway and network analysis of genes related to osteoporosis
- A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantification
- Assessment of the gene expression profiles of leukocytes from different isolations
Related papers
- Illuminating the dark protein-protein interactome
- Plant Protein-Protein Interaction Network and Interactome
- The social and structural architecture of the yeast protein interactome
- The social architecture of an in-depth cellular protein interactome
- Mapping a Lung Cancer Interactome to Isolate New Targets
- The elusive yeast interactome
- The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions
- Yeast two-hybrid system for dissecting the rice MAPK interactome.