The elusive yeast interactome
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Summary
Two new comprehensive studies of the yeast interactome show that simple eukaryotic cells such as yeast could contain around 800 protein complexes, but slightly different approaches resulted in surprising differences between the two datasets.
- Type
- review
- Published
- 2006-06-30
- Cited by
- 92
- References
- 18
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979330259
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10270005
Keywords
Interactome, Yeast, Computational biology, Saccharomyces cerevisiae, Simple (philosophy)
References
- Mass spectrometry-based proteomics
- Global analysis of protein phosphorylation in yeast
- A novel genetic system to detect proteinprotein interactions
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
- Proteome survey reveals modularity of the yeast cell machinery
- A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
- A quantitative protein interaction network for the ErbB receptors using protein microarrays
- Functional organization of the yeast proteome by systematic analysis of protein complexes
- The third dimension for protein interactions and complexes.
- The spindle pole body component Spc97p interacts with the γ‐tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication
- A critical and Integrated View of the Yeast Interactome
- Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
- The interactome of human EGF/ErbB receptors
- Spc98p and Spc97p of the yeast γ‐tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p
- The Yeast Spindle Pole Body Component Spc72p Interacts with Stu2p and Is Required for Proper Microtubule Assembly
- A comprehensive two-hybrid analysis to explore the yeast protein interactome
- The TAP Project
- Global Analysis of Protein Activities Using Proteome Chips
Cited by
- Network approaches to the functional analysis of microbial proteins.
- Genome Mapping and Genomics in Laboratory Animals
- Knowledge derivation and data mining strategies for probabilistic functional integrated networks
- Determining protein interaction specificity of native and designed bZIP family transcription factors
- A structural classification of protein-protein interactions for detection of convergently evolved motifs and for prediction of protein binding sites on sequence level
- Identificazione di complessi proteici coinvolti in specifici processi cellulari
- Novel approaches to the integration and analysis of systems biology data
- Computational and experimental methods in functional genomics : the good, the bad, and the ugly of systems biology
- Coupling protein complex analysis to peptide based proteomics.
- Proteomic analysis of protein complexes
- Quantitative maps of genetic interactions in yeast - Comparative evaluation and integrative analysis
- Computational analysis of human protein interaction networks
- Protein-protein interactions: from global to local analyses.
- Retention of protein complex membership by ancient duplicated gene products in budding yeast.
- An optimized predictive strategy for interactome mapping.
- The Binary Protein Interactome of Treponema pallidum – The Syphilis Spirochete
- Extracting high confidence protein interactions from affinity purification data: at the crossroads.
- Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
- Plant proteomics: concepts, applications, and novel strategies for data interpretation.
- SPINE: A method for the rapid detection and analysis of protein–protein interactions in vivo
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