Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
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Summary
A large genome-wide association study of clinically diagnosed Alzheimer's disease and AD-by-proxy identifies new loci and functional pathways that contribute to AD risk and adds novel insights into the neurobiology of AD.
- Type
- review
- Published
- 2019-01-07
- Cited by
- 2,021
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2908002252
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:57574588
Keywords
Biology, Mendelian randomization, Genome-wide association study, Disease, Genetics
References
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- Large-scale whole-genome sequencing of the Icelandic population
- Head Circumference as a Measure of Cognitive Reserve
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- Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
- MAGMA: Generalized Gene-Set Analysis of GWAS Data
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
- Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids and Alzheimer's Disease
- Integrative analysis of 111 reference human epigenomes
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- Genetic variability in the regulation of gene expression in ten regions of the human brain
Cited by
- Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
- Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
- Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease
- Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives.
- Effects of Species-Specific Genetics on Alzheimer's Mouse Models.
- Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer’s disease: meta-analysis of 11 cohort studies
- Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models
- A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
- Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s Disease
- Alzheimer disease risk genes: 29 and counting
- Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
- Alzheimer disease and Apolipoprotein E4: meningeal brain lymphatics point to new clues in pathogenesis
- Shared genes between Alzheimer’s disease and ischemic stroke
- The ARNTL polymorphism rs900147 is associated with the risk of Alzheimer’s disease and amnestic mild cognitive impairment in a Chinese population
- Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
- Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer’s Disease
- HDL from an Alzheimer's disease perspective
- Evaluation of CD33 as a Genetic Risk Factor for Alzheimer’s Disease
- Accelerated evolution of oligodendrocytes in human brain
- Sex differences in gene expression patterns associated with the APOE4 allele
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