Effects of Species-Specific Genetics on Alzheimer's Mouse Models.
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Summary
The generation of Alzheimer's disease transgenic mouse models on a panel of 28 background strains shows marked background-dependent phenotypic variability, implying that analogous variation in human AD phenotypes may be due, at least in part, to subtle effects of genetic background.
- Type
- letter
- Published
- 2019-02-01
- Cited by
- 8
- References
- 5
- Access
- Open access
- OpenAlex
- https://openalex.org/W2912173386
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:72335322
Keywords
Neuroscience, Biology, Genetics, Evolutionary biology, Computational biology
References
- Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology.
- A three-dimensional human neural cell culture model of Alzheimer’s disease
- Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- Harnessing genetic complexity to enhance translatability of Alzheimer’s disease mouse models: a path towards experimental precision medicine
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- Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice
- Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the APPswePS1dE9 mouse model
- Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells
- Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites
- Critical thinking of Alzheimer’s transgenic mouse model: current research and future perspective
- Neuroprotection beyond neurons: integrated biomarker-based and astroglia- or microglia-targeted approaches to combat neurodegenerative diseases
- Impact of Alzheimer's disease on brain and behavior in mice: Magnetic resonance microscopy resolves widespread effects
- Recombinant Inbred Mice as Models for Experimental Precision Medicine and Biology
- Experimental precision medicine: Mouse models in which to test precision medicine
- The Mouseion at the JAXlibrary The Mouseion at the JAXlibrary Identifying the molecular systems that influence cognitive Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice. resilience to Alzheimer's disease in genetically diverse
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