MicroRNAs in diabetic wound healing: pathophysiology and therapeutic opportunities
Explore this paper's citation graph
Summary
This work summarizes the versatile roles of miRNAs implicated in diabetic wound healing in key stages including inflammation, angiogenesis, re-epithelialization, and remodeling and highlights current evidence through which miRNA exert control of gene expression and signaling pathways in the reparative response that may provide opportunities for therapeutic intervention for this potentially devastating disease state.
- Type
- review
- Published
- 2018-08-08
- Cited by
- 65
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W2885026326
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52079238
Keywords
microRNA, Wound healing, Disease, Inflammation, Angiogenesis
References
- Cellular and molecular basis of wound healing in diabetes.
- Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a
- microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts.
- Angiogenic signalling pathways.
- Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing.
- Adhesion molecules and inflammatory injury
- Dynamic Reciprocity in the Wound Microenvironment
- Angiogenesis in cancer and other diseases
- Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice.
- Transforming Growth Factor‐β
- MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis?
- MicroRNA miR-27b Rescues Bone Marrow–Derived Angiogenic Cell Function and Accelerates Wound Healing in Type 2 Diabetes Mellitus
- Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights
- Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
- miR-191: an emerging player in disease biology
- The pathway to foot ulceration in diabetes.
- MicroRNA signature in diabetic wound healing: promotive role of miR‐21 in fibroblast migration
- Aging and Wound Healing
- Angiogenesis in health and disease
- The biology of VEGF and its receptors
Cited by
- MicroRNA‐135a‐3p regulates angiogenesis and tissue repair by targeting p38 signaling in endothelial cells
- Post-transcriptional markers associated with clinical complications in Type 1 and Type 2 diabetes mellitus.
- MicroRNA-615-5p regulates angiogenesis and tissue repair by targeting AKT/eNOS signaling in endothelial cells
- Nanocarrier-based systems for wound healing
- Editorial commentary: Wanted: MicroRNAs to the aid of the diabetic foot.
- Engineered Human Adipose Stem Cell-derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing.
- Maggot excretions/secretions promote diabetic wound angiogenesis via miR18a/19a -TSP-1 axis.
- Dysregulation of microRNA expression in diabetic skin.
- Approaches to Modulate the Chronic Wound Environment Using Localized Nucleic Acid Delivery
- miR-27-3p inhibition restore fibroblasts viability in diabetic wound by targeting NOVA1
- MicroRNAs in Shaping the Resolution Phase of Inflammation
- Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
- Exosomes derived from ADSCs containing miR‐378 promotes wound healing by targeting caspase‐3
- Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction
- Down-Regulation of miR-138 Alleviates Inflammatory Response and Promotes Wound Healing in Diabetic Foot Ulcer Rats via Activating PI3K/AKT Pathway and hTERT
- Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach
- Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds
- Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting Notch signaling
- Landscape of the epigenetic regulation in wound healing
- The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
Related papers
- The vasohibin family: a novel family for angiogenesis regulation.
- The vasohibin family: Novel regulators of angiogenesis.
- A novel in vitro angiogenesis model based on a microfluidic device
- A PlGF-1 Derived Peptide Inhibits Angiogenesis via HIF-1β/VEGF Pathway
- An endothelium-derived angiogenesis inhibitor vasohibin and its significance in tumor angiogenesis
- Update on endogenous inhibitors of angiogenesis.
- Dual Role of MicroRNAs in NAFLD
- MicroRNA-Based Diagnosis and Therapy