Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
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Summary
A mathematical model predicts how spatial distribution of VEGF-A produced by delivery of a modified mRNA accelerates diabetic wound healing and highlights the critical need to consider the location of drug delivery and diffusivity of the drug, parameters not typically explored in pre-clinical experiments, when designing and testing drugs for treating diabetic wounds.
- Type
- article
- Published
- 2021-06-15
- Cited by
- 5
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W3167300026
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:236155816
Keywords
Wound healing, VEGF receptors, Messenger RNA, Acceleration, Computational biology
References
- Determinants and estimation of healing times in diabetic foot ulcers.
- Cellular and molecular basis of wound healing in diabetes.
- A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury
- Wound healing in the patient with diabetes mellitus.
- Clinical Application of Growth Factors and Cytokines in Wound Healing
- Surgical Approaches to Create Murine Models of Human Wound Healing
- Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing.
- Modeling the effects of treating diabetic wounds with engineered skin substitutes
- Therapeutic Approaches to the Regulation of Wound Angiogenesis
- Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice
- Defining a model to predict the distribution of topically applied growth factors and other solutes in excisional full-thickness wounds.
- Crawling Cells Can Close Wounds without Purse Strings or Signaling
- A Three Species Model to Simulate Application of Hyperbaric Oxygen Therapy to Chronic Wounds
- A reaction-diffusion model to study RNA motion by quantitative fluorescence recovery after photobleaching.
- An in silico approach to the analysis of acute wound healing
- A Modeling Approach to Study the Effect of Cell Polarization on Keratinocyte Migration
- Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers.
- Computational and Mathematical Modeling of Angiogenesis
- Wound healing and its impairment in the diabetic foot.
- Computational Modeling of Inflammation and Wound Healing
Cited by
- 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
- In silico optimization of heparin microislands in microporous annealed particle (MAP) hydrogel for endothelial cell migration
- mRNA vaccines in disease prevention and treatment
- Understanding the ideal wound healing mechanistic behavior using in silico modelling perspectives: A review.
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