Macrophage targeting: opening new possibilities for cancer immunotherapy
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Summary
Several animal studies suggest that tumour‐infiltrating myeloid cells, especially TAM, are one of the key targets to improve the efficacy of immunotherapies as these cells can suppress the functions of CD8+ T and NK cells.
- Type
- review
- Published
- 2018-07-31
- Cited by
- 145
- References
- 76
- Access
- Open access
- OpenAlex
- https://openalex.org/W2809740307
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49639172
Keywords
CTL*, Adoptive cell transfer, Cytotoxic T cell, Immune system, Cancer research
References
- IL-12: a promising adjuvant for cancer vaccination
- The breast tumor microenvironment alters the phenotype and function of natural killer cells
- STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion1
- CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
- CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
- Tumor-associated macrophages: from mechanisms to therapy
- Chemokine (C-C Motif) Ligand 2 Engages CCR2+ Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone*
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
- Neoantigens in cancer immunotherapy
- The immunobiology of cancer immunosurveillance and immunoediting.
- Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide
- Macrophages and therapeutic resistance in cancer
- CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells
- Immune Checkpoint Targeting in Cancer Therapy: Towards Combination Strategies with Curative Potential
- Monocyte/macrophage‐elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions
- Marginating Dendritic Cells of the Tumor Microenvironment Cross-present Tumor Antigens and Stably Engage Tumor-Specific T cells
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- Prospects for the use of NK cells in immunotherapy of human cancer
- Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Cited by
- Low Baseline Serum Sodium Concentration Is Associated with Poor Clinical Outcomes in Metastatic Non-Small Cell Lung Cancer Patients Treated with Immunotherapy
- Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors
- Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression
- Evaluating CAR-T Cell Therapy in a Hypoxic 3-D Tumor Model
- Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells.
- Recent progress on developing exogenous monocyte/macrophage-based therapies for inflammatory and degenerative diseases.
- Precision immunomodulation with synthetic nucleic acid technologies
- Facing the future: challenges and opportunities in adoptive T cell therapy in cancer
- A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
- RAW 264.7 Macrophage Polarization by Pancreatic Cancer Cells – A Model for Studying Tumour-promoting Macrophages
- Plasma-Derived Reactive Species Shape a Differentiation Profile in Human Monocytes
- Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay
- Ontogeny of Tumor-Associated Macrophages
- Tuning the Tumor Myeloid Microenvironment to Fight Cancer
- The pro-tumorigenic host response to cancer therapies
- Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation
- T Cell Reprogramming Against Cancer
- Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer.
- Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo
- Oncogenic signaling pathways associated with immune evasion and the resistance to immune checkpoint inhibitors in cancer.
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